DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and TMTC2

DIOPT Version :9

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_689801.1 Gene:TMTC2 / 160335 HGNCID:25440 Length:836 Species:Homo sapiens


Alignment Length:328 Identity:65/328 - (19%)
Similarity:117/328 - (35%) Gaps:100/328 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 SKSVTTDKLQSERDSLYER--LQAQLKNLSQL--EKEQFAERHRLRGNESFKAKEYENAIEEYNC 254
            |:|..::...:.|::||.|  :...|.||..|  |..:|||                 |:..|..
Human   505 SQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAE-----------------ALHYYKL 552

  Fly   255 SIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIK---AH--------LRMAEAH 308
            :|...|..| .||.|..:..:...:...|......|.:|...|:|   ||        ..:.:.:
Human   553 AIGSRPTLA-SAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLY 616

  Fly   309 NAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGEV------------------------- 348
            :.:|.:.|:|:|||:.:...|    .:.|.:.|.:|:||.                         
Human   617 HEQGHYEEALSVYKEAIQKMP----RQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHI 677

  Fly   349 --------------APSSATRLIIE--EIDPPQ-----------------LKTSEPKKEAEKSEP 380
                          ..|.|.:|.::  |:||.:                 ::.:|..|:|.:.:.
Human   678 PAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDS 742

  Fly   381 T---VVKKPEPVV--SAKKPPPIKDYDLAELVKPNRMVKSNLVSAAEALGNKMQASKGGAPKKPQ 440
            |   ||.....::  ::......|.||||..::||.......:.|...|..::|.::....:..|
Human   743 TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQ 807

  Fly   441 SPP 443
            ..|
Human   808 LKP 810

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 TPR_11 229..295 CDD:290150 13/65 (20%)
TPR repeat 229..257 CDD:276809 4/27 (15%)
TPR repeat 262..293 CDD:276809 6/30 (20%)
TPR_11 266..329 CDD:290150 16/73 (22%)
TPR 266..297 CDD:197478 6/30 (20%)
TPR repeat 298..326 CDD:276809 9/38 (24%)
TMTC2NP_689801.1 DUF1736 247..318 CDD:285594
TPR 1 462..492
TPR_11 493..554 CDD:290150 16/65 (25%)
TPR 2 493..526 6/20 (30%)
TPR repeat 493..521 CDD:276809 3/15 (20%)
TPR_1 493..>520 CDD:278916 3/14 (21%)
TPR 3 527..560 12/49 (24%)
TPR repeat 527..555 CDD:276809 10/44 (23%)
TPR_12 557..634 CDD:290160 18/77 (23%)
TPR repeat 560..590 CDD:276809 6/30 (20%)
TPR 4 562..594 6/31 (19%)
TPR repeat 595..634 CDD:276809 9/38 (24%)
TPR 5 606..639 7/36 (19%)
TPR_2 609..638 CDD:285020 7/32 (22%)
TPR repeat 642..671 CDD:276809 4/28 (14%)
TPR 6 643..676 4/32 (13%)
TPR_11 645..708 CDD:290150 8/62 (13%)
TPR 7 677..710 6/32 (19%)
TPR repeat 679..705 CDD:276809 3/25 (12%)
TPR repeat 710..774 CDD:276809 11/63 (17%)
TPR 8 712..744 3/31 (10%)
TPR 9 746..778 8/31 (26%)
TPR_19 755..822 CDD:291240 12/56 (21%)
TPR 10 779..812 5/32 (16%)
TPR_1 779..812 CDD:278916 5/32 (16%)
TPR repeat 779..807 CDD:276809 3/27 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1124
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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