Protein Alignment Spag1 and Ifit3

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: XP_011245453.1
• Gene: Ifit3 / 15959
• MGIID: 1101055
• Length: 434
• Species: Mus musculus
• Alignment Length: 469
• Identity: 93/469 - (19%)
• Similarity: 166/469 - (35%)
• Gaps: 176/469 - (37%)

  Fly    48 HYPDLQRCAEEKLKALKPDSK------LFRYEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNE 106
            |..::.|   |.|:|:.|..|      |||   :...|:.::                 |...|:
Mouse    31 HANEVNR---ESLEAILPQLKCHFTWNLFR---EGSMSSHME-----------------DRVCNQ 72

  Fly   107 LKKVKQNLNLPSVRKLSKID-------LEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWD 164
            ::      :|.|..|.:..|       |:.|||..                .|...::.|.||
Mouse    73 VE------HLNSEEKATMYDLLAYIKHLDGESKAA----------------LECLGQAEDLRK-- 113

  Fly   165 KYDPDEEILRMDLNEERDQEQREKIIS--NHSKSVTTDKLQSERDSLYERLQAQLKNLS------ 221
                         :|..||.:..::::  |::.........||..:..::::...:..:
Mouse   114 -------------SEHNDQSEIRRLVTWGNYAWIYYHMGRLSEAQAYVDKVRQVCQKFANPYSME 165

  Fly   222 --QLEKEQFAERHRLRGNESFKAKE-YENAIEEYNCSIIYDPENAVHAYNNRAVAHLKL----KK 279
              :||.|:...|.:...||  :||. :|.|:||..    .|||    ..:..|:|..:|    :|
Mouse   166 CPELECEEGWTRLKCGRNE--RAKMCFEKALEEKP----KDPE----CSSGMAIAMFRLEEKPEK 220

  Fly   280 YFSAISDCQACLQIDPMN--------IKAHLRMAEAHNAEGKHL---------ESLNVYKKLLDF 327
            .|| :...:..::::|.|        :|. |||.|  .|||:.|         ...:|.:|...|
Mouse   221 QFS-VDALKQAMELNPQNQYLKVLLALKL-LRMGE--EAEGERLIKDALGKAPNQTDVLQKAAQF 281

  Fly   328 EPDNAIAKKAVEKLTSMLGEVAPSSAT--------RLIIEEIDPPQLKTSEPKKEAEKSE----- 379
            ........:|:|.|...|.....:|..        |.|:|::        :.|.:|:.||
Mouse   282 YKKKGNLDRAIELLGKALRSTVNNSPLYSLVMCRYREILEQL--------QNKGDADSSERRQRM 338

  Fly   380 ------------PTVVKKPEP------------------VVSAKKPPPIKDYDLAE----LVKPN 410
                        .|:.::..|                  :|.:|:.|.:::.||.|    |.:.:
Mouse   339 AELRRLTMEFMQKTLQRRRSPLNSYSDLIDFPEVERCYQMVISKESPDVEEEDLYERYCNLQEYH 403

  Fly   411 RMVKSNLVSAAEAL 424
            |  ||..::|.|.|
Mouse   404 R--KSEDLAALECL 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	40/173 (23%)
		TPR repeat	229..257	CDD:276809	9/28 (32%)
		TPR repeat	262..293	CDD:276809	6/34 (18%)
		TPR repeat	298..326	CDD:276809	11/36 (31%)
Ifit3	XP_011245453.1	TPR_12	82..157	CDD:315987	15/105 (14%)
		TPR repeat	82..110	CDD:276809	6/43 (14%)
		TPR repeat	115..154	CDD:276809	6/38 (16%)
		TPR	127..368	CDD:440225	52/262 (20%)
		TPR repeat	167..195	CDD:276809	10/29 (34%)
		TPR repeat	200..233	CDD:276809	9/37 (24%)
		TPR repeat	272..300	CDD:276809	6/27 (22%)