DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Spag1 and TTC16

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_659402.1	Gene:	TTC16 / 158248	HGNCID:	26536	Length:	873	Species:	Homo sapiens

Alignment Length:	566	Identity:	103/566 - (18%)
Similarity:	188/566 - (33%)	Gaps:	198/566 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LKPDSKLFRYE-------------------EQIKQSTD-----LDKTEL-----KPILDWTD--- 95
            |:|:...|||.                   .::||.|.     :.:..|     ||.|.:.|
Human   165 LQPEKPCFRYRCMACLLALKQHQACLTLITNELKQDTTNADVYIFRARLYNFLQKPHLCYRDLHS 229

  Fly    96 ----------AIKTKDNALNELKKVKQNLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKN 150
                      |.......:.:.::.:|:..:.:|:...:..|::.::..:..|    ..||
Human   230 ALLLNPKHPQARMLLQKMVAQAQQARQDAGILAVQGKLQHALQRINRAIENNP----LDPS---- 286

  Fly   151 KEARIKSTDYRKWDKYDPDEE----ILRMDLNEERD---QEQREKIISNHSKSV----------- 197
             ....:.|.||:..::|...|    :|.|...::.|   |.||:.:::.:..:|
Human   287 -LFLFRGTMYRRLQEFDGAVEDFLKVLDMVTEDQEDMVRQAQRQLLLTYNDFAVHCYRQGAYQEG 350

  Fly   198 -------TTDKLQSERDSLYERLQA--QLKNLS-------------------------QLEKEQF 228
                   ..|: |.|:.....|...  ||.||:                         ..||..|
Human   351 VLLLNKALRDE-QQEKGLYINRGDCFFQLGNLAFAEADYQQALALSPQDEGANTRMGLLQEKMGF 414

  Fly   229 AERHRLRGNESFKAKEYENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQI 293
            .|:.|         |:::.|...::.:|.::|:.|.: |..||.:...|:..|.|..|....|.:
Human   415 CEQRR---------KQFQKAENHFSTAIRHNPQKAQY-YLYRAKSRQLLQNIFGARQDVATVLLL 469

  Fly   294 DPMNIKAHLRMA---------EAHNAEGKHLESLNVYK------------------KLLDFEPDN 331
            :|...|..|.|.         |..:.:..||..|.:.:                  |..:.|...
Human   470 NPKQPKLSLLMTNLFPGMSVEEVLSTQIAHLARLQLEQMVEGSLQAGSPQGIVGMLKRHELERQK 534

  Fly   332 A-------------IAKKAVEKLTSMLGEVAPSSATRLIIEEIDPPQLKTSEPKKEAEKSEPTVV 383
            |             ||.....|.|..:.:|.|.|:.    .|.:.|:   .|.:||.||.|.
Human   535 ALALQHSWKQGEPLIATSEELKATPEIPQVKPGSSE----GEAEAPE---EEEEKEKEKKEE--- 589

  Fly   384 KKPEPVVSAKKPPPIKD---------------------YDLAELVKPNRMVKSNLVSAAEALGNK 427
            ||.|.:.|  |...:.|                     .:::.:.:..|...:..|:.:::...|
Human   590 KKSELIPS--KVASLSDSYLDQTSSASSMSFRTTGTSETEMSAICQEYRSTSATAVTFSDSSLLK 652

  Fly   428 MQASKGG--------APKKPQSPPMTPKETLLRL--PQDNLNNSNK 463
            .|:|..|        .|:|.:: ....:::|.:.  .|....||:|
Human   653 TQSSDSGNNREALSHGPRKIKA-TQGQRQSLSKTEPTQSQRRNSSK 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	15/65 (23%)
		TPR repeat	229..257	CDD:276809	4/27 (15%)
		TPR repeat	262..293	CDD:276809	9/30 (30%)
		TPR_11	266..329	CDD:290150	17/89 (19%)
		TPR	266..297	CDD:197478	9/30 (30%)
		TPR repeat	298..326	CDD:276809	8/54 (15%)
TTC16	NP_659402.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		TPR 1	61..94
		TPR repeat	61..89	CDD:276809
		TPR_11	62..124	CDD:290150
		TPR repeat	94..124	CDD:276809
		TPR 2	96..128
		TPR repeat	129..164	CDD:276809
		TPR 3	136..169		2/3 (67%)
		TPR repeat	169..199	CDD:276809	3/29 (10%)
		TPR repeat	204..231	CDD:276809	5/26 (19%)
		TPR repeat	237..280	CDD:276809	4/42 (10%)
		TPR 4	251..284		4/36 (11%)
		TPR_11	<264..314	CDD:290150	10/58 (17%)
		TPR 5	285..318		9/37 (24%)
		TPR repeat	285..313	CDD:276809	7/32 (22%)
		TPR 6	331..364		3/33 (9%)
		TPR_11	332..396	CDD:290150	9/64 (14%)
		TPR repeat	333..359	CDD:276809	1/25 (4%)
		TPR repeat	364..394	CDD:276809	6/29 (21%)
		TPR 7	365..398		5/32 (16%)
		TPR_11	367..437	CDD:290150	13/78 (17%)
		TPR_1	368..398	CDD:278916	5/29 (17%)
		TPR repeat	399..434	CDD:276809	7/43 (16%)
		TPR 8	406..439		9/41 (22%)
		TPR_11	407..471	CDD:290150	18/73 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..626		19/84 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..873		12/60 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810