DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and Ifit1bl2

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001349059.1	Gene:	Ifit1bl2 / 112419	MGIID:	2148249	Length:	466	Species:	Mus musculus

Alignment Length:	405	Identity:	76/405 - (18%)
Similarity:	129/405 - (31%)	Gaps:	122/405 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKKKSLLERYNIPIHY-LDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCAEEKLKALKPDS 67
            :|.:.:.:.::.|..| |:.|.:: |.....:.|      .|.: :|.....|.|..|| ::|::
Mouse   124 DKVEKVCKEFSSPFRYRLECAEMD-CEEGWALRK------CGSQ-NYTRAMACFERALK-VEPEN 179

  Fly    68 KLFR--YEEQIKQSTDLDKTELKPILDWTDAIKTKDNALNELKKVKQNLNLPSVRKLSKID---- 126
            ..:.  |.:........|...|:| |....::|.:|..|    ||...|.|..:||..:.:
Mouse   180 PEYNAGYADVAYHLDYYDGNSLQP-LKKAVSVKPEDPYL----KVLLALKLQDLRKTDEAEKHIK 239

  Fly   127 --------------------------------LEKESKTEKPKP----------------APKAT 143
                                            |:|..:|:...|                ..|||
Mouse   240 EATLTISSQNNIFGYVAKFYRRKGCVEEALGFLKKALETKPSSPYLHFQIGLCHKTQFFQMKKAT 304

  Fly   144 SPSNTK--NKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQEQREKIISNHSKSVTTDKLQSER 206
            |..|.|  ::...:....::|..:..|..:...:||        .|....||.:....|..|
Mouse   305 SRENRKRADQSCHLAICHFKKTLELKPTYDRAYIDL--------AEVYAKNHQQKEAEDNFQ--- 358

  Fly   207 DSLYERLQAQLKNLSQLEKEQFAERHRLRGN-ESFKAKEYENAIEEYNCSIIYDPENAVHAYNNR 270
                     ::.::|.|......|.|...|| :.:..|..|.||..|           :......
Mouse   359 ---------EVLSMSNLGDYMQQEIHFRYGNFQQYYKKSEEAAITHY-----------LKGLKIE 403

  Fly   271 AVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAK 335
            ..:|.:.|.                  :||...:||... |...||||::...:.....|.:.|.
Mouse   404 VTSHYRDKL------------------LKALEELAEGRK-EDHVLESLSLLGLVCRLRGDTSEAM 449

  Fly   336 KAVEKLTSMLGEVAP 350
            ...||...:.|.|.|
Mouse   450 SCYEKALRLTGAVNP 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	11/66 (17%)
		TPR repeat	229..257	CDD:276809	9/28 (32%)
		TPR repeat	262..293	CDD:276809	2/30 (7%)
		TPR_11	266..329	CDD:290150	11/62 (18%)
		TPR	266..297	CDD:197478	2/30 (7%)
		TPR repeat	298..326	CDD:276809	9/27 (33%)
Ifit1bl2	NP_001349059.1	TPR_11	<63..>353	CDD:330823	45/250 (18%)
		TPR repeat	63..94	CDD:276809
		TPR repeat	99..129	CDD:276809	1/4 (25%)
		TPR repeat	144..174	CDD:276809	7/37 (19%)
		TPR repeat	179..210	CDD:276809	5/31 (16%)
		TPR repeat	215..241	CDD:276809	7/29 (24%)
		TPR repeat	282..329	CDD:276809	8/46 (17%)
		TPR_11	<324..>458	CDD:330823	35/183 (19%)
		TPR repeat	334..362	CDD:276809	7/47 (15%)
		TPR repeat	372..401	CDD:276809	9/39 (23%)
		TPR repeat	429..457	CDD:276809	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900