Protein Alignment Spag1 and TOMM34

DIOPT Version :10

• Sequence 1: NP_651514.1
• Gene: Spag1 / 43239
• FlyBaseID: FBgn0039463
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_006800.2
• Gene: TOMM34 / 10953
• HGNCID: 15746
• Length: 309
• Species: Homo sapiens
• Alignment Length: 368
• Identity: 74/368 - (20%)
• Similarity: 131/368 - (35%)
• Gaps: 123/368 - (33%)

  Fly    35 EKIVQILRSGEE----GHYPDLQRCAEEKLKALK------PDSKLFRYEEQ-------------I 76
            :.:.::..:|.|    |.|.:........|:.|:      |:.:...|..:             |
Human     7 DSVEELRAAGNESFRNGQYAEASALYGRALRVLQAQGSSDPEEESVLYSNRAACHLKDGNCRDCI 71

  Fly    77 KQSTD---LDKTELKPIL-----------------DWTDAIKTKDNALNELKKVKQ--------- 112
            |..|.   |....:||:|                 |:...::..||..:.::.:.:
Human    72 KDCTSALALVPFSIKPLLRRASAYEALEKYPMAYVDYKTVLQIDDNVTSAVEGINRMTRALMDSL 136

  Fly   113 ----NLNLPSVRKLSKIDLEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEIL 173
                .|.|||:..:             |..|.|                    :|:..
Human   137 GPEWRLKLPSIPLV-------------PVSAQK--------------------RWNSL------- 161

  Fly   174 RMDLNEERDQEQREKIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNE 238
                    ..|..:::..:.||..|..|             .::.:...:||.:..:.   .|||
Human   162 --------PSENHKEMAKSKSKETTATK-------------NRVPSAGDVEKARVLKE---EGNE 202

  Fly   239 SFKAKEYENAIEEYNCSII-YDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHL 302
            ..|...::.|||:|:.|:: .:.|:|  .|:|||:.:|.||:|..|:.||...|::|..|:||..
Human   203 LVKKGNHKKAIEKYSESLLCSNLESA--TYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFY 265

  Fly   303 RMAEAHNAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSML 345
            |.|:||.|...:..|......||..||.|..|:|..:::...|
Human   266 RRAQAHKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNL 308

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	NlpI	<229..373	CDD:443815	41/118 (35%)
		TPR repeat	229..257	CDD:276809	9/27 (33%)
		TPR repeat	262..293	CDD:276809	13/30 (43%)
		TPR repeat	298..326	CDD:276809	9/27 (33%)
TOMM34	NP_006800.2	TPR 1	9..42		6/32 (19%)
		TPR repeat	9..37	CDD:276809	4/27 (15%)
		3a0801s09	<12..>294	CDD:273380	70/347 (20%)
		TPR repeat	50..80	CDD:276809	4/29 (14%)
		TPR 2	51..84		5/32 (16%)
		TPR repeat	85..113	CDD:276809	4/27 (15%)
		TPR 3	86..118		5/31 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	161..189		5/55 (9%)
		TPR 4	193..226		9/35 (26%)
		TPR repeat	193..221	CDD:276809	9/30 (30%)
		TPR repeat	226..256	CDD:276809	14/31 (45%)
		TPR 5	227..260		14/34 (41%)
		TPR repeat	261..289	CDD:276809	9/27 (33%)
		TPR 6	262..294		12/31 (39%)