DRSC/TRiP Functional Genomics Resources

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Protein Alignment Spag1 and Bbs4

DIOPT Version :10

Sequence 1:NP_651514.1 Gene:Spag1 / 43239 FlyBaseID:FBgn0039463 Length:469 Species:Drosophila melanogaster
Sequence 2:NP_780534.1 Gene:Bbs4 / 102774 MGIID:2143311 Length:520 Species:Mus musculus


Alignment Length:529 Identity:102/529 - (19%)
Similarity:174/529 - (32%) Gaps:175/529 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MEKEKKKS-------LLERYN--IPIHYLDFAHVEKCTNAREMEKIVQILRSGEEGHYPDLQRCA 56
            :|.:|.:|       ::|:.|  |.:||:          .::.|....:::.    ...:.|...
Mouse    16 VESQKPRSKKAPDFPIVEKQNWLIHLHYI----------RKDYEACKAVIKE----QLQETQGLC 66

  Fly    57 EEKLKALKPDSKLFRYEEQIKQSTDLDKT--ELKPILDWTDAIKTKDNALNELKKVKQNLNLPSV 119
            |   .|:...:.:||.|..|::|.:|.:|  .|.|        :..||    ||:|.::|.|...
Mouse    67 E---YAIYVQALIFRLEGNIQESLELFQTCAVLSP--------QCADN----LKQVARSLFLLGK 116

  Fly   120 RKLSKIDLEKESKTEKPKPAPKATSPSNTKNKEARIKSTDYRKWDKYDPDEEILRMDLNEERDQE 184
            .|                      :.:...|:.|::...|:          ||.           
Mouse   117 HK----------------------AATEVYNEAAKLNQKDW----------EIC----------- 138

  Fly   185 QREKIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKE-----QFAERHRLRGNESFKAKE 244
                    |:..|....|:.     :.:.|.||.:..||.|.     ...:.|.|:|       :
Mouse   139 --------HNLGVCYTYLKQ-----FNKAQDQLHSALQLNKHDLTYIMLGKIHLLQG-------D 183

  Fly   245 YENAIEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRMAEAHN 309
            .:.|||.|..::.:.||| ........:.:|:|..|..|.......|..||.|.||.|.......
Mouse   184 LDKAIEIYKKAVEFSPEN-TELLTTLGLLYLQLGVYQKAFEHLGNALTYDPANYKAILAAGSMMQ 247

  Fly   310 AEGKHLESLNVYKKLLDFEPD-----NAIA------KKAVEKLTSM--LGEVAP----------- 350
            ..|....:|..|:.:....|:     |.|.      ||.|..::.:  ...:||           
Mouse   248 THGDFDVALTKYRVVACAIPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGL 312

  Fly   351 --------SSATRLIIEEID-PPQ-----------LKTSEPKKEAEKS--EPTVVKKPEPVVS-- 391
                    :||...:...|: .|:           |...|..:.|.::  |...:.|..|:|:  
Mouse   313 VHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENARRAYVEAVRLDKCNPLVNLN 377

  Fly   392 --------AKKPPPIKDYDLAELVKPNRMVKSN--------LVSAAEALGNKMQASKGGAPKKPQ 440
                    .:|...:..|.  |:.|....:|.|        :|..|:.||..:|..:.....||.
Mouse   378 YAVLLYNQGEKKSALAQYQ--EMEKKVNFLKDNSPLEFDSEMVEMAQKLGAALQVGEALVWTKPV 440

  Fly   441 SPPMTPKET 449
            ..|.|...|
Mouse   441 KDPKTKHRT 449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Spag1NP_651514.1 NlpI <229..373 CDD:443815 38/187 (20%)
TPR repeat 229..257 CDD:276809 7/27 (26%)
TPR repeat 262..293 CDD:276809 6/30 (20%)
TPR repeat 298..326 CDD:276809 6/27 (22%)
Bbs4NP_780534.1 Required for localization to centrosomes. /evidence=ECO:0000250 1..66 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26 3/9 (33%)
BepA 66..201 CDD:443813 41/212 (19%)
TPR 1 67..100 11/43 (26%)
TPR repeat 68..95 CDD:276809 8/26 (31%)
Interaction with PCM1. /evidence=ECO:0000250 101..337 58/303 (19%)
TPR repeat 101..129 CDD:276809 9/53 (17%)
TPR repeat 134..164 CDD:276809 9/63 (14%)
LapB 141..398 CDD:442196 53/271 (20%)
TPR repeat 169..196 CDD:276809 7/33 (21%)
TPR repeat 202..229 CDD:276809 4/26 (15%)
TPR repeat 236..264 CDD:276809 6/27 (22%)
TPR repeat 270..298 CDD:276809 5/27 (19%)
TPR repeat 303..333 CDD:276809 3/29 (10%)
Required for localization to centrosomes. /evidence=ECO:0000250 338..520 23/114 (20%)
TPR repeat 338..366 CDD:276809 4/27 (15%)
TPR repeat 372..397 CDD:276809 4/26 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 488..520
Blue background indicates that the domain is not in the aligned region.

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