DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and tomm70

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001096527.1	Gene:	tomm70 / 100125169	XenbaseID:	XB-GENE-1007952	Length:	577	Species:	Xenopus tropicalis

Alignment Length:	285	Identity:	76/285 - (26%)
Similarity:	124/285 - (43%)	Gaps:	66/285 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 EERDQEQREKIISNHSKSVTTDKLQSERDSLYERLQAQLKNLSQLEKEQFAERHRLRGNESFKAK 243
            |:||:::|       :.......:.:|..|......|. :.||.|||.|.|:.   :||:.|||.
Frog    44 EKRDKQRR-------TPEGRASPVPAEGSSTNNPQDAP-QELSPLEKAQAAKN---KGNKYFKAS 97

  Fly   244 EYENAIEEYNCSIIYDP----ENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMNIKAHLRM 304
            :||.||:.|..:|...|    .:....|.|||.||.:|:.:...:.||...::::|..:||..|.
Frog    98 KYEQAIQCYTEAISLCPVDTKSDLSTFYQNRAAAHEQLQNWKEVVQDCTKAVELNPRYVKALFRR 162

  Fly   305 AEAH---NAEGKHLESLNVYKKLLDFEPDNAIAKKAVEKLTSMLGE------------VAPSSAT 354
            |:||   :.:.:.||.:.....|..|:  |..:....:|:..:||:            :.||
Frog   163 AKAHERLDNKKECLEDVTAVCILEGFQ--NQQSMFLADKVLKLLGKEKAKDKYKNREPLMPS--- 222

  Fly   355 RLIIEEIDPPQLKT----------SEPKKEAEKS--------EPTVVKKPEPVVSAKKPPPIKDY 401
                    |..:|:          |:|.::.|||        |..|||:....:.|||....::|
Frog   223 --------PQFIKSYFSSFTDDIISQPLQKGEKSDEDKDKEGEAAVVKEKSGYLKAKKYMEEENY 279

  Fly   402 D--LAELVKPNRMVKSNLVSAAEAL 424
            |  ::|..|.   |:|.....||||
Frog   280 DKIISECTKE---VESVGKYVAEAL 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	22/69 (32%)
		TPR repeat	229..257	CDD:276809	11/27 (41%)
		TPR repeat	262..293	CDD:276809	9/30 (30%)
		TPR_11	266..329	CDD:290150	20/65 (31%)
		TPR	266..297	CDD:197478	10/30 (33%)
		TPR repeat	298..326	CDD:276809	9/30 (30%)
tomm70	NP_001096527.1	3a0801s09	20..570	CDD:273380	76/285 (27%)
		TPR repeat	83..111	CDD:276809	12/30 (40%)
		TPR repeat	116..151	CDD:276809	9/34 (26%)
		TPR repeat	298..326	CDD:276809	4/4 (100%)
		TPR repeat	331..365	CDD:276809
		TPR repeat	370..398	CDD:276809
		TPR repeat	404..438	CDD:276809
		TPR repeat	445..473	CDD:276809
		TPR repeat	478..509	CDD:276809
		TPR repeat	514..541	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940