DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Spag1 and aip

DIOPT Version :9

Sequence 1:	NP_651514.1	Gene:	Spag1 / 43239	FlyBaseID:	FBgn0039463	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001096219.1	Gene:	aip / 100124770	XenbaseID:	XB-GENE-947114	Length:	328	Species:	Xenopus tropicalis

Alignment Length:	181	Identity:	38/181 - (20%)
Similarity:	64/181 - (35%)	Gaps:	36/181 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 RMDLNEERDQEQREKIISNHSKSVTTDKLQSERDS---LYERLQAQLKNLSQLEKEQFAERHRLR 235
            |.|.....|||:.|.:...|.:.....|.....|:   .||.: |.||:|..  |||       .
Frog   163 RQDAWAMTDQEKMEAVPVLHQEGNQLYKQGKTNDAAAKYYEAI-ACLKSLQM--KEQ-------P 217

  Fly   236 GNESFKAKEYENA---IEEYNCSIIYDPENAVHAYNNRAVAHLKLKKYFSAISDCQACLQIDPMN 297
            |:..:.|.:.:..   :....|.::..                   .|:..:..|.:.|.....|
Frog   218 GSPDWIALDLKITPLLLNYCQCKLLEG-------------------DYYQVLEHCSSILNKYSDN 263

  Fly   298 IKAHLRMAEAHNAEGKHLESLNVYKKLLDFEPDNA-IAKKAVEKLTSMLGE 347
            :||..:...||.|.....|:...:.:.:..:|..| :..|.::||...|.|
Frog   264 VKALFKRGRAHAAVWNASEAERDFSRAVSLDPSLAPLVAKEMKKLEERLHE 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Spag1	NP_651514.1	TPR_11	229..295	CDD:290150	6/68 (9%)
		TPR repeat	229..257	CDD:276809	3/30 (10%)
		TPR repeat	262..293	CDD:276809	3/30 (10%)
		TPR_11	266..329	CDD:290150	10/62 (16%)
		TPR	266..297	CDD:197478	3/30 (10%)
		TPR repeat	298..326	CDD:276809	6/27 (22%)
aip	NP_001096219.1	FKBP_C	28..>89	CDD:388582
		3a0801s09	169..>320	CDD:273380	36/175 (21%)
		TPR repeat	180..206	CDD:276809	5/26 (19%)
		TPR repeat	229..259	CDD:276809	4/48 (8%)
		TPR repeat	264..292	CDD:276809	6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1535
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030