DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ets97D and gabpa

DIOPT Version :9

Sequence 1:	NP_001263000.1	Gene:	Ets97D / 43236	FlyBaseID:	FBgn0004510	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001315341.1	Gene:	gabpa / 58110	ZFINID:	ZDB-GENE-011010-2	Length:	455	Species:	Danio rerio

Alignment Length:	494	Identity:	176/494 - (35%)
Similarity:	258/494 - (52%)	Gaps:	85/494 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SNDLSDELIRRLSVGGALEEVIASEMFEDSIDVETEAEPDDIIIVHMDIREPLSMLKSLVEQKIG 68
            |...::|:| .:.:.|..::    |..|:.|:.:| ....::|...:||.||:..||.|:|.::.
Zfish     2 SKSETEEMI-EIEIDGREKQ----ECLEEGIEEQT-ITAAELITQDIDINEPIGNLKKLLEPRLQ 60

  Fly    69 VCLNYYTFWLQDAQELESHKNLVDQCVKGEGLVQINVQIQTI--RKRINIADVLKPTEAALAALA 131
            :.|:.|...|||.| |....:|.||.||.:|.||::|||.|.  .:::||.:::||.|..
Zfish    61 IPLDGYDICLQDIQ-LHPDHSLFDQGVKTDGTVQLSVQIVTKPGEEKLNILEIVKPVETV----- 119

  Fly   132 EEVVGQLSPPETASQKSSSSESPIKTPLKRMHKEDSEEESVEGKDVKPVLNWVLDSK-FKREQIR 195
             |||  :.|...|.:::...|......::|....|...|.        |..|....: :::||:|
Zfish   120 -EVV--IDPDAAAGEEAHLVEDGQVIAVERAALPDETSEQ--------VTRWAAALEGYRKEQVR 173

  Fly   196 LKIPEAANEWTHAHVTYWLEWAVKQFELVGINMSDWQMNGQELCAMTHEEFNQKLPRDPGNIFWT 260
            |.||....:||...|.:|..|.:|:|.:..:.:....:.|::||..:.|||.|::|  .|.|.|:
Zfish   174 LNIPYDPVQWTADQVIHWAVWVMKEFGIDEMEVGGIHIPGRQLCGFSQEEFLQRVP--SGEILWS 236

  Fly   261 HLQLLKECNFVSVVHKRAEE-----------------QRKPKQPRIMSANSISTNSGGSLSLEQR 308
            ||:||::  :|.....:::|                 |..|...::|..|  .|.....:|.|:|
Zfish   237 HLELLRK--YVLASQDQSQEATVTIDQPVQIIPAPVQQATPTAIKVMKHN--KTPRAPRISGEER 297

  Fly   309 IMRKSYQSVKSSDSVESTTSSMNPSNYTTIGSGNNGQVQLWQFLLEILTDCEHTDVIEWVGTEGE 373
                                 .:|.|.|    |||||:||||||||:|||.:..|.|.|||.|||
Zfish   298 ---------------------SSPGNRT----GNNGQIQLWQFLLELLTDKDSRDCISWVGEEGE 337

  Fly   374 FKLTDPDRVARLWGEKKNKPAMNYEKLSRALRYYYDGDMISKVSGKRFAYKFDCDLKLLIGYDAN 438
            |||..|:.||:.||::||||.||||||||||||||||||||||.||||.|||.|||:.||||.|.
Zfish   338 FKLNQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMISKVQGKRFVYKFVCDLRTLIGYSAA 402

  Fly   439 ELSTLVSEGKTAPERVAATE---------TITEDTXHGE 468
            ||:.||:|  ...:::|..:         |:|..| .|:
Zfish   403 ELNNLVTE--CEQKKLARVQLQGLGQPVNTVTLATATGQ 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets97D	NP_001263000.1	GABP-alpha	48..123	CDD:288472	30/76 (39%)
		SAM_PNT-GABP-alpha	184..272	CDD:176084	28/88 (32%)
		ETS	345..429	CDD:197710	62/83 (75%)
gabpa	NP_001315341.1	GABP-alpha	40..118	CDD:288472	31/78 (40%)
		SAM_PNT-GABP-alpha	162..248	CDD:176084	29/89 (33%)
		ETS	309..394	CDD:197710	63/84 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590639
Domainoid	1	1.000	132	1.000	Domainoid score	I5094
eggNOG	1	0.900	-	-		E1_KOG3806
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1543
Inparanoid	1	1.050	262	1.000	Inparanoid score	I3082
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	1	1.000	-	-		FOG0008382
OrthoInspector	1	1.000	-	-		oto40164
orthoMCL	1	0.900	-	-		OOG6_108754
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4554
SonicParanoid	1	1.000	-	-		X6369
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.830