DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets97D and Gabpa

DIOPT Version :9

Sequence 1:	NP_001263000.1	Gene:	Ets97D / 43236	FlyBaseID:	FBgn0004510	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	XP_008766806.1	Gene:	Gabpa / 363735	RGDID:	1310802	Length:	456	Species:	Rattus norvegicus

Alignment Length:	457	Identity:	176/457 - (38%)
Similarity:	253/457 - (55%)	Gaps:	58/457 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SDELIRRLSVGGALEEVIASEMFEDSIDVETEAEPDDIIIVHMDIREPLSMLKSLVEQKIGVCLN 72
            ::||| .:.:.|..:    .|..|:|| ||....|.:.:...:||.||:..||.|:|.::...|:
  Rat     6 AEELI-EIEIDGTEK----PECTEESI-VEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQCSLD 64

  Fly    73 YYTFWLQDAQELESHKNLVDQCVKGEGLVQINVQI---QTIRKRINIADVLKPTEAALAALAEEV 134
            .:...|||.| |:..::|.||.||.:|.||::||:   |.|..::||.:::|..|..      ||
  Rat    65 AHEICLQDIQ-LDPDRSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKTAETV------EV 122

  Fly   135 VGQLSPPETASQKSSSSESPIKTPLKRMHKEDSEEESVEGKDVKPVLNWVLDSK-FKREQIRLKI 198
            |.........::.....|:.:.|.....|.....:|:.|     .|..|....: :::||.||.|
  Rat   123 VIDPDAHHAEAEAHLVEEAQVITLDGTKHITTISDETSE-----QVTRWAAALEGYRKEQERLGI 182

  Fly   199 PEAANEWTHAHVTYWLEWAVKQFELVGINMSDWQMNGQELCAMTHEEFNQKLPRDPGNIFWTHLQ 263
            |....:|:...|.:|:.|.:|:|.:..|:::...::|:|||::..|:|.|::||  |.|.|:||:
  Rat   183 PYDPIQWSTDQVLHWVVWVMKEFSMTDIDLTTLNISGRELCSLNQEDFFQRVPR--GEILWSHLE 245

  Fly   264 LLKECNFVSVVHKRAEEQRKPK-----QP-RIMSANSIST--------NSGGSLSLEQRIMRKSY 314
            ||::....|      :||:..:     || :|:.|:..|.        ||....:..||..|.|.
  Rat   246 LLRKYVLAS------QEQQMNEIVTIDQPVQIIPASVPSATPTTIKVINSSAKAAKVQRSPRISG 304

  Fly   315 QSVKSSDSVESTTSSMNPSNYTTIGSGNNGQVQLWQFLLEILTDCEHTDVIEWVGTEGEFKLTDP 379
            :...|            |.|.|.:  |||||:||||||||:|||.:..|.|.|||.||||||..|
  Rat   305 EDRSS------------PGNRTDL--GNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQP 355

  Fly   380 DRVARLWGEKKNKPAMNYEKLSRALRYYYDGDMISKVSGKRFAYKFDCDLKLLIGYDANELSTLV 444
            :.||:.||::||||.|||||||||||||||||||.||.||||.|||.||||.||||.|.||:.||
  Rat   356 ELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLV 420

  Fly   445 SE 446
            :|
  Rat   421 TE 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets97D	NP_001263000.1	GABP-alpha	48..123	CDD:288472	29/77 (38%)
		SAM_PNT-GABP-alpha	184..272	CDD:176084	29/88 (33%)
		ETS	345..429	CDD:197710	61/83 (73%)
Gabpa	XP_008766806.1	GABP-alpha	40..119	CDD:288472	29/79 (37%)
		SAM_PNT-GABP-alpha	168..254	CDD:176084	29/87 (33%)
		ETS	321..405	CDD:197710	61/83 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166349366
Domainoid	1	1.000	130	1.000	Domainoid score	I5108
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1543
Inparanoid	1	1.050	267	1.000	Inparanoid score	I2955
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	1	1.000	-	-		FOG0008382
OrthoInspector	1	1.000	-	-		oto98800
orthoMCL	1	0.900	-	-		OOG6_108754
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6369
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.900