DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ets97D and gabpa

DIOPT Version :9

Sequence 1:	NP_001263000.1	Gene:	Ets97D / 43236	FlyBaseID:	FBgn0004510	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_001116494.1	Gene:	gabpa / 100126064	XenbaseID:	XB-GENE-987250	Length:	454	Species:	Xenopus tropicalis

Alignment Length:	451	Identity:	178/451 - (39%)
Similarity:	244/451 - (54%)	Gaps:	65/451 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ASEMFEDSIDVETEAE-PDDIIIVH-----------MDIREPLSMLKSLVEQKIGVCLNYYTFWL 78
            |.|:.|..||...:.| .::.||.|           :||.||:..||.|:|.::...|:.:...|
Frog     6 AEELIEIEIDGTEKTECTEESIIEHTYSTAEFISQSIDINEPVGNLKKLLEPRLQCSLDAHEICL 70

  Fly    79 QDAQELESHKNLVDQCVKGEGLVQINVQI---QTIRKRINIADVLKPTEAALAALAEEVVGQLSP 140
            ||.| |:..::|.||.||.:|.||::||:   |.:..::||.:::||.|..      |||.....
Frog    71 QDIQ-LDPDRSLFDQGVKTDGSVQLSVQVISQQGLEPKLNILEIVKPVETV------EVVIDPDA 128

  Fly   141 PETASQKSSSSESPIKT-----PLKRMHKEDSEEESVEGKDVKPVLNWVLDSK-FKREQIRLKIP 199
            .:.|.:.....|:.:.|     .:..|..|.||:          |..|....: :::||.||.||
Frog   129 HQDAVEAELVEEAQVITLDGSKHITTMSDETSEQ----------VTRWAAALEGYRKEQERLGIP 183

  Fly   200 EAANEWTHAHVTYWLEWAVKQFELVGINMSDWQMNGQELCAMTHEEFNQKLPRDPGNIFWTHLQL 264
            ....:|:...|.:|:.|.:|:|.|..||::...:.|:|||.:..|:|.|::||  |.|.|:||:|
Frog   184 YDPLQWSVDQVLHWVLWVMKEFCLTEINVNSLGITGRELCNLNQEDFFQRVPR--GEILWSHLEL 246

  Fly   265 LKECNFVSVVHKRAEEQRKPKQP-RIMSANSIST--------NSGGSLSLEQRIMRKSYQSVKSS 320
            |::....|..|..........|| :|:.|:...|        ||...::..||..|.|.:...|
Frog   247 LRKYVLASQEHGGEIATVTIDQPVQIIPASIQPTAQTTIKVINSQTKVAKIQRTPRISGEDRSS- 310

  Fly   321 DSVESTTSSMNPSNYTTIGSGNNGQVQLWQFLLEILTDCEHTDVIEWVGTEGEFKLTDPDRVARL 385
                       |.|.|    |||||:||||||||:|||.:..|.|.|||.||||||..|:.||:.
Frog   311 -----------PGNRT----GNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKLNQPELVAQK 360

  Fly   386 WGEKKNKPAMNYEKLSRALRYYYDGDMISKVSGKRFAYKFDCDLKLLIGYDANELSTLVSE 446
            ||::||||.|||||||||||||||||||.||.||||.|||.||||.||||.|.|||.||:|
Frog   361 WGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELSRLVAE 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ets97D	NP_001263000.1	GABP-alpha	48..123	CDD:288472	29/88 (33%)
		SAM_PNT-GABP-alpha	184..272	CDD:176084	31/88 (35%)
		ETS	345..429	CDD:197710	61/83 (73%)
gabpa	NP_001116494.1	GABP-alpha	40..119	CDD:371630	29/79 (37%)
		SAM_PNT-GABP-alpha	168..254	CDD:176084	31/87 (36%)
		ETS	320..404	CDD:197710	61/83 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I9529
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1543
Inparanoid	1	1.050	233	1.000	Inparanoid score	I3340
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243757at33208
OrthoFinder	1	1.000	-	-		FOG0008382
OrthoInspector	1	1.000	-	-		oto105495
Panther	1	1.100	-	-	LDO	PTHR11849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4554
SonicParanoid	1	1.000	-	-		X6369
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.100