Protein Alignment ro and EVX2

DIOPT Version :10

• Sequence 1: NP_524521.1
• Gene: ro / 43234
• FlyBaseID: FBgn0003267
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_001073927.1
• Gene: EVX2 / 344191
• HGNCID: 3507
• Length: 476
• Species: Homo sapiens
• Alignment Length: 335
• Identity: 92/335 - (27%)
• Similarity: 125/335 - (37%)
• Gaps: 91/335 - (27%)

  Fly    18 KRSDSLDPIANTTILSV-----------PQRPSSP----------RQFFE--RLYG--HLETRSS 57
            ||..:|...|...:|..           |:.||:|          :..||  .|:.  |..:.|:
Human    23 KRFSNLSNSAGNAVLEALENSQHPARLSPRLPSAPLHSALGELPAKGKFEIDTLFNLQHTGSEST 87

  Fly    58 ENGEIDVGTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSLAAYPAYDFYGHA-------KDYP 115
            .:.||.....:.|.|    .::|:  :.:..|:| ||.....:|..:....|.|       |.|.
Human    88 VSSEISSAAESRKKP----GHYSE--AAAEADMS-SDVEVGCSALRSPGGLGAAQLKENNGKGYA 145

  Fly   116 QHPSQQHQQHHHHHHHPPQLVHQKLSYVSPPPAIAAGGAANPVLPHAFPAGFPSDPHFSAGFSAF 180
            :..|                        :.....:|.|:....| |....|        :|.||.
Human   146 ESGS------------------------AAGTTTSASGSGLGSL-HGGSGG--------SGGSAA 177

  Fly   181 LARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAK 245
            |........:.||.||.|:.||..|||.||:|..|:||.||.|||..|.|.||.||:||||||.|
Human   178 LGGSGSGADQVRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMK 242

  Fly   246 DKRIEKAQIDQHYRNFVVANGFMSSIMGQAATT---------------MPPGGVTGGVAVGVGLN 295
            |||...|....|..:    ..|.:.:|..||.|               .|..|||...|......
Human   243 DKRQRLAMSWPHPAD----PSFYTYMMTHAAATGSLPYPFHSHVPLHYYPHVGVTAAAAAAAASG 303

  Fly   296 YYAAAATPAA 305
            ..|||::|.|
Human   304 AAAAASSPFA 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeodomain	196..248	CDD:459649	32/51 (63%)
EVX2	NP_001073927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	82..113		6/36 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	142..185		12/75 (16%)
		Homeodomain	189..245	CDD:459649	35/55 (64%)