DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ro and HOXD3

DIOPT Version :9

Sequence 1:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_008829.3	Gene:	HOXD3 / 3232	HGNCID:	5137	Length:	432	Species:	Homo sapiens

Alignment Length:	322	Identity:	88/322 - (27%)
Similarity:	119/322 - (36%)	Gaps:	72/322 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 LSVPQRPSSPRQFFERL-----YGHLETRSSENGEIDVGTHAHKPPPC-----DTPYHSDGGSVS 86
            |.:|:.......::|..     ||:.:|..:.....   .|...|||.     ||.|.....|:.
Human    10 LELPECTMQKAAYYENPGLFGGYGYSKTTDTYGYST---PHQPYPPPAAASSLDTDYPGSACSIQ 71

  Fly    87 SPDISISDERTSLAAYPAYDFYGHAKDYPQHPSQQHQQHHHHHHHPPQL--VHQKLSYVSPPPAI 149
                  |.......|:...:..|..    ..|...:.|.......||.|  ..|......|||.:
Human    72 ------SSAPLRAPAHKGAELNGSC----MRPGTGNSQGGGGGSQPPGLNSEQQPPQPPPPPPTL 126

  Fly   150 AAGGAANP--VLPHAFPAGFPSDPHFSAGFSAFL---ARRRRKEGRQ------------------ 191
            ......||  .:|...|.|.|:....||..|..:   .:..|:..:|
Human   127 PPSSPTNPGGGVPAKKPKGGPNASSSSATISKQIFPWMKESRQNSKQKNSCATAGESCEDKSPPG 191

  Fly   192 ---RRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDKRIEKAQ 253
               :|.||.:::.|.:.||.|||.|.|:.|.||.|:|..|.|||.||||||||||.|.|:.:||:
Human   192 PASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKAK 256

  Fly   254 IDQHYRNFVVANGFMSSIMGQAATTMPP-GGVTGGVAVG------VGLNYYAAAATPAALPK 308
                        |.:.|...|:....|| ||..|.||..      .||.|  .|.:|.|..|
Human   257 ------------GILHSPASQSPERSPPLGGAAGHVAYSGQLPPVPGLAY--DAPSPPAFAK 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeobox	196..247	CDD:278475	29/50 (58%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..62		5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..197		24/138 (17%)
		Antp-type hexapeptide	160..165		0/4 (0%)
		Homeobox	198..250	CDD:306543	30/51 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	253..280		10/38 (26%)
		DUF4074	369..430	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..432
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810