DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ro and HOXB8

DIOPT Version :9

Sequence 1:NP_524521.1 Gene:ro / 43234 FlyBaseID:FBgn0003267 Length:350 Species:Drosophila melanogaster
Sequence 2:NP_076921.1 Gene:HOXB8 / 3218 HGNCID:5119 Length:243 Species:Homo sapiens


Alignment Length:216 Identity:66/216 - (30%)
Similarity:86/216 - (39%) Gaps:64/216 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    36 QRPSSPRQFFERLYGHLETRSSENGEIDVGTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSLA 100
            |.||..::|:             :|...:.|..::..||....|.|.|                 
Human    49 QHPSQIQEFY-------------HGPSSLSTAPYQQNPCAVACHGDPG----------------- 83

  Fly   101 AYPAYDFYGHAKDYPQHPSQQHQQHHHHHHHPPQLVHQ---KLSYVSPPPAIAAGGAANPVLPHA 162
                 :|||:  |..|..|....|       .|.||..   ||:..|.....|.|...:|.....
Human    84 -----NFYGY--DPLQRQSLFGAQ-------DPDLVQYADCKLAAASGLGEEAEGSEQSPSPTQL 134

  Fly   163 FPAGFPSDPHFSAGFSAFLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAET 227
            ||.   ..|..:||         |:.|||     |:|..|||.||.||..|.|::|.||.|::..
Human   135 FPW---MRPQAAAG---------RRRGRQ-----TYSRYQTLELEKEFLFNPYLTRKRRIEVSHA 182

  Fly   228 LRLTETQIKIWFQNRRAKDKR 248
            |.|||.|:||||||||.|.|:
Human   183 LGLTERQVKIWFQNRRMKWKK 203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
roNP_524521.1 Homeobox 196..247 CDD:278475 29/50 (58%)
HOXB8NP_076921.1 Antp-type hexapeptide 134..139 2/7 (29%)
Homeobox 150..203 CDD:395001 31/57 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..243 0/1 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000007
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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