DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ro and HOXB5

DIOPT Version :9

Sequence 1:NP_524521.1 Gene:ro / 43234 FlyBaseID:FBgn0003267 Length:350 Species:Drosophila melanogaster
Sequence 2:NP_002138.1 Gene:HOXB5 / 3215 HGNCID:5116 Length:269 Species:Homo sapiens


Alignment Length:202 Identity:64/202 - (31%)
Similarity:84/202 - (41%) Gaps:48/202 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    53 ETRSSENGEIDVGTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSL---AAYPAYDFYGHAKDY 114
            |:....||:    :|..||            |.|||    ||:.||.   |.:...| ...|...
Human    98 ESLPCTNGD----SHGAKP------------SASSP----SDQATSASSSANFTEID-EASASSE 141

  Fly   115 PQHPSQQHQQHHHHHHHPPQLVHQKLSYVSPPPAIAAGGAANPVLPHAFPAGFPSDPHFSAGFSA 179
            |:..:.             ||....|:...|.|...:..|.....|..||  :....|.|...:.
Human   142 PEEAAS-------------QLSSPSLARAQPEPMATSTAAPEGQTPQIFP--WMRKLHISHDMTG 191

  Fly   180 FLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRA 244
                   .:|  :|.||.::..|||.||.|||.|.|::|.||.|:|..|.|:|.||||||||||.
Human   192 -------PDG--KRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRM 247

  Fly   245 KDKRIEK 251
            |.|:..|
Human   248 KWKKDNK 254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
roNP_524521.1 Homeobox 196..247 CDD:278475 30/50 (60%)
HOXB5NP_002138.1 PRK07003 <67..>171 CDD:235906 24/106 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 77..173 24/108 (22%)
Antp-type hexapeptide 176..181 2/6 (33%)
Homeobox 198..251 CDD:395001 31/52 (60%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000007
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.900

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