DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ro and HOXB4

DIOPT Version :9

Sequence 1:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_076920.1	Gene:	HOXB4 / 3214	HGNCID:	5115	Length:	251	Species:	Homo sapiens

Alignment Length:	156	Identity:	52/156 - (33%)
Similarity:	71/156 - (45%)	Gaps:	36/156 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 SPPPAIAAGGAANPVLPHAF---PAGFP---------SDPHFSAGFSAFLARRRRKEGRQRRQRT 196
            ||||...|....:|...|:.   |..:|         .:|:::.             |..:|.||
Human   116 SPPPPPCAQNPLHPSPSHSACKEPVVYPWMRKVHVSTVNPNYAG-------------GEPKRSRT 167

  Fly   197 TFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDKRIEKAQIDQHYRNF 261
            .::.:|.|.||.|||.|.|::|.||.|:|..|.|:|.||||||||||.|.|:      |....|.
Human   168 AYTRQQVLELEKEFHYNRYLTRRRRVEIAHALCLSERQIKIWFQNRRMKWKK------DHKLPNT 226

  Fly   262 VVANGFMSSIMGQAATTMPPGGVTGG 287
            .:.:|..:...|.     |||...||
Human   227 KIRSGGAAGSAGG-----PPGRPNGG 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeobox	196..247	CDD:278475	29/50 (58%)
HOXB4	NP_076920.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..134		6/17 (35%)
		Antp-type hexapeptide	141..146		1/4 (25%)
		Homeobox	165..218	CDD:278475	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	220..251		9/33 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900