DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ro and HOXA3

DIOPT Version :9

Sequence 1:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_001371264.1	Gene:	HOXA3 / 3200	HGNCID:	5104	Length:	443	Species:	Homo sapiens

Alignment Length:	312	Identity:	81/312 - (25%)
Similarity:	110/312 - (35%)	Gaps:	110/312 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RHKVEIGSPDGSPGIKRSDSLDPIANTTILSVPQRPSSPRQFFERLYGHLETRSSENGEIDVGTH 67
            |....:.||..:.|..::..|......|:.:.|.:|.|                  .||..:
Human    47 RPACSLQSPSSAGGHPKAHELSEACLRTLSAPPSQPPS------------------LGEPPL--- 90

  Fly    68 AHKPPPCDTPYHSDGGSVSSPDISISDERTSLAAYPAYDFYGHAKDYPQHPSQQHQQHHHHHHHP 132
             |.|||                         .||.||          ||.|....|        |
Human    91 -HPPPP-------------------------QAAPPA----------PQPPQPAPQ--------P 111

  Fly   133 PQLVHQKLSYVSPPPAIA------------AGGAANPVL--PHAFPAGFP-----------SDPH 172
            |    .......|||:.|            |..|.:|:|  |......||           ....
Human   112 P----APTPAAPPPPSSASPPQNASNNPTPANAAKSPLLNSPTVAKQIFPWMKESRQNTKQKTSS 172

  Fly   173 FSAGFSAFLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKI 237
            .|:|.|....:....:...:|.||.:::.|.:.||.|||.|.|:.|.||.|:|..|.|||.||||
Human   173 SSSGESCAGDKSPPGQASSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKI 237

  Fly   238 WFQNRRAKDKRIEKAQIDQHYRNFVVANGFMSSIMGQ--AATTMPPGGVTGG 287
            ||||||.|.|:.:|.:            |.::|..||  :.:.:|||  .||
Human   238 WFQNRRMKYKKDQKGK------------GMLTSSGGQSPSRSPVPPG--AGG 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeobox	196..247	CDD:278475	29/50 (58%)
HOXA3	NP_001371264.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..147		26/140 (19%)
		Antp-type hexapeptide	155..160		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..196		4/36 (11%)
		Homeobox	195..248	CDD:395001	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	247..338		11/43 (26%)
		DUF4074	378..441	CDD:404218
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810