Protein Alignment ro and HHEX

DIOPT Version :10

• Sequence 1: NP_524521.1
• Gene: ro / 43234
• FlyBaseID: FBgn0003267
• Length: 350
• Species: Drosophila melanogaster
• Sequence 2: NP_002720.1
• Gene: HHEX / 3087
• HGNCID: 4901
• Length: 270
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 73/264 - (27%)
• Similarity: 105/264 - (39%)
• Gaps: 94/264 - (35%)

  Fly     9 GSPDGSPGIKRSDSLDPI-ANTTILSVPQRPSSPRQFF-ERLYGHLETRSSENGEIDVGTHAHKP 71
            |...|:.|:       |: |.|.:|    :|:.|..|: |.:.|.             |..|..|
Human     7 GPAAGAVGV-------PLYAPTPLL----QPAHPTPFYIEDILGR-------------GPAAPTP 47

  Fly    72 PPCDTPYHSDGGSVSSPDIS----ISDERTSLAAYPAYDFYGHAKDYPQHPSQQHQQHHHHHHHP 132
            .|          ::.||:.|    :|..||     |.|:           |:..|....||
Human    48 AP----------TLPSPNSSFTSLVSPYRT-----PVYE-----------PTPIHPAFSHH---- 82

  Fly   133 PQLVHQKLSYVSPPPAIAAGGAANPVLP---------HAF----PAGFPSDPHFSAGFSAFLAR- 183
                    |..:...|...||...|:.|         ||.    |.|.|      ..:|.||.|
Human    83 --------SAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKP------LLWSPFLQRP 133

  Fly   184 -RRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDK 247
             .:||.|:.|     ||.:||:.||.:|...:|:|...|..||:.|:|:|.|:|.||||||||.:
Human   134 LHKRKGGQVR-----FSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWR 193

  Fly   248 RIEK 251
            |:::
Human   194 RLKQ 197

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeodomain	196..248	CDD:459649	25/51 (49%)
HHEX	NP_002720.1	Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982	1..137		43/197 (22%)
		Homeodomain	136..194	CDD:459649	29/62 (47%)
		Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982	137..270		30/66 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	194..270		1/4 (25%)