DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ro and hoxd3a

DIOPT Version :9

Sequence 1:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_571200.1	Gene:	hoxd3a / 30349	ZFINID:	ZDB-GENE-990415-120	Length:	396	Species:	Danio rerio

Alignment Length:	320	Identity:	83/320 - (25%)
Similarity:	122/320 - (38%)	Gaps:	114/320 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SDSLDPIANTTILSVPQRPSSPRQFFERLYGHLETRSSENGEIDVGTHAHKPPPCDTPYHSDGGS 84
            :|...||.       |.:.:|.||           .:.:||:|: |:       |..|..|.|.
Zfish    40 NDYQSPIC-------PIQTTSVRQ-----------ATHKNGDIN-GS-------CMRPSASQGN- 77

  Fly    85 VSSPDISISDERTS--LAAYPAYDFYGHAKDYPQHPSQQHQQHHHHHHHPPQLVHQKLSYVSPPP 147
             |.|: |||:::.:  |||         :...|...|.|.::                     .|
Zfish    78 -SQPE-SISEQQQAAPLAA---------SSPSPSTNSTQKKK---------------------SP 110

  Fly   148 AIAAGGAANPVL-PHAFP------------------AGFPSDPHFSAGFSAFLARRRRKEGRQRR 193
            :......|.||: ...||                  ||...|.....|.::            :|
Zfish   111 SSNGSSTATPVISKQIFPWMKETRQNAKQKSTNCPAAGETCDDKSPPGPAS------------KR 163

  Fly   194 QRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDKRIEKAQIDQHY 258
            .||.:::.|.:.||.|||.|.|:.|.||.|:|..|.|||.||||||||||.|.|:.:|::
Zfish   164 VRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKSK----- 223

  Fly   259 RNFVVANGFMSSIMGQAATTMPPGGVTGGVAVGV--------GLNYYAAAATPAALPKDN 310
                   |.|.|.:|.:....||  ::|...:|.        .|:|.|.:....|.|:.|
Zfish   224 -------GIMHSPLGHSPDRSPP--LSGSNHIGYSGQLPNVNSLSYDAPSPPSFAKPQQN 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeobox	196..247	CDD:278475	29/50 (58%)
hoxd3a	NP_571200.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..163		36/193 (19%)
		Abdominal-A	116..237	CDD:332641	46/144 (32%)
		Antp-type hexapeptide	126..131		2/4 (50%)
		Homeobox	165..217	CDD:306543	30/51 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..246		8/40 (20%)
		DUF4074	333..394	CDD:315871
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810