DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ro and Hoxd4

DIOPT Version :9

Sequence 1:NP_524521.1 Gene:ro / 43234 FlyBaseID:FBgn0003267 Length:350 Species:Drosophila melanogaster
Sequence 2:NP_034599.2 Gene:Hoxd4 / 15436 MGIID:96208 Length:250 Species:Mus musculus


Alignment Length:226 Identity:66/226 - (29%)
Similarity:89/226 - (39%) Gaps:73/226 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    70 KPPPCD------------TPYHSDG--GSVSSPDISISDERTSLAAYPAYDF----YGHAKDYPQ 116
            |.|||:            ..|:..|  |:...|.          ..||..||    :|.....|.
Mouse    16 KFPPCEEYLQGGYLGEQGADYYGSGAQGADFQPS----------GLYPRPDFGEQPFGGGGPGPG 70

  Fly   117 H--PSQQHQQH----HHHHHHPPQLVHQKLSYVSPPPAIAAGGAA--NPVLPHAFPAG------- 166
            .  |::.|.|.    ..|:..|.:      ...:||||...|..|  .|..|...|.|       
Mouse    71 SALPARGHGQEPSGPGSHYGAPGE------RCPAPPPAPLPGARACSQPTGPKQPPPGTALKQPA 129

  Fly   167 --FP---------SDPHFSAGFSAFLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSR 220
              :|         .:|:::.             |..:|.||.::.:|.|.||.|||.|.|::|.|
Mouse   130 VVYPWMKKVHVNSVNPNYTG-------------GEPKRSRTAYTRQQVLELEKEFHFNRYLTRRR 181

  Fly   221 RFELAETLRLTETQIKIWFQNRRAKDKRIEK 251
            |.|:|.||.|:|.||||||||||.|.|:..|
Mouse   182 RIEIAHTLCLSERQIKIWFQNRRMKWKKDHK 212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
roNP_524521.1 Homeobox 196..247 CDD:278475 30/50 (60%)
Hoxd4NP_034599.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..126 25/110 (23%)
Antp-type hexapeptide 131..136 1/4 (25%)
Homeobox 155..208 CDD:278475 31/52 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 210..250 1/3 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0489
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000007
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.900

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