DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ro and Hoxa1

DIOPT Version :9

Sequence 1:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster
Sequence 2:	NP_037207.2	Gene:	Hoxa1 / 103690132	RGDID:	11414885	Length:	334	Species:	Rattus norvegicus

Alignment Length:	240	Identity:	76/240 - (31%)
Similarity:	100/240 - (41%)	Gaps:	73/240 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PSSPRQFFERLYGHLETRSSENGEIDV-GTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSLAA 101
            ||...|.|...||..    ..|.|.|| |.:    |||....:|  |::|||.:
  Rat    96 PSYGAQNFSAPYGPY----GLNQEADVSGGY----PPCAPAVYS--GNLSSPMV----------- 139

  Fly   102 YPAYDFYGHAKDYPQHPSQQHQQHHHHHH-------HPPQLVHQKLSYVSPPPAIAAGGAANPVL 159
                                  ||||||.       ..||.:|.  ||.....::|.....|.:.
  Rat   140 ----------------------QHHHHHQGYAGGTVGSPQYIHH--SYGQEHQSLALATYNNSLS 180

  Fly   160 P-HA-------FPAGFPSDPHFSAGFSAFLARRRRKE----------GRQRRQRTTFSTEQTLRL 206
            | ||       .||...|.|  :..|.....:|...:          |:....||.|:|:|...|
  Rat   181 PLHASHQEACRSPASETSSP--AQTFDWMKVKRNPPKTGKVGEYGYVGQPNAVRTNFTTKQLTEL 243

  Fly   207 EVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRAKDKRIEK 251
            |.|||.|:|::|:||.|:|.:|:|.|||:||||||||.|.|:.||
  Rat   244 EKEFHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREK 288

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ro	NP_524521.1	Homeobox	196..247	CDD:278475	30/50 (60%)
Hoxa1	NP_037207.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..82
		Interaction with OGT. /evidence=ECO:0000250\|UniProtKB:P09022	74..202		39/152 (26%)
		COG5576	175..>285	CDD:227863	42/111 (38%)
		Antp-type hexapeptide	203..208		1/4 (25%)
		Homeobox	232..284	CDD:278475	31/51 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..334		5/9 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45946
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010