Protein Alignment Rb97D and RBM39

DIOPT Version :10

• Sequence 1: NP_524520.1
• Gene: Rb97D / 43231
• FlyBaseID: FBgn0004903
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_909122.1
• Gene: RBM39 / 9584
• HGNCID: 15923
• Length: 530
• Species: Homo sapiens
• Alignment Length: 261
• Identity: 63/261 - (24%)
• Similarity: 100/261 - (38%)
• Gaps: 53/261 - (20%)

  Fly     5 EPLSDESADVIVLADREEDDICELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAAT 69
            ||:.:       |...|.|       .|.:|...||......:|:.|:...|||.||.::.|..:
Human   140 EPIDN-------LTPEERD-------ARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNS 190

  Fly    70 KRSRGFGFITYTKSLMVDRA-----QE--NRPHIIDGKTVEAKRALPRPERESRETNISVKKLFV 127
            :||:|..::.:.....|..|     |.  ..|.|:.....|..||... ....::.:....:|:|
Human   191 RRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAM-ANNLQKGSAGPMRLYV 254

  Fly   128 GGLKDNHDEECLREYFLQFGNVVSVKLLTDKTTGKRRGFAFVEFDDYDAVDKAI----------- 181
            |.|..|..|:.||..|..||.:.|::|:.|..||:.:|:.|:.|.|.:...||:
Human   255 GSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGR 319

  Fly   182 -LKKQHAIKYVHVDVKKSIYNLDKKEKQQPG-----------------GLANAIKPSLNQQQQQQ 228
             :|..|..:  ..|...:...||..|.::.|                 |....|.|:..|..|..
Human   320 PMKVGHVTE--RTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMS 382

  Fly   229 G 229
            |
Human   383 G 383

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_524520.1	RRM2_hnRNPA_like	124..196	CDD:409766	25/83 (30%)
		RRM_SF	33..110	CDD:473069	22/83 (27%)
RBM39	NP_909122.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..146		2/12 (17%)
		SF-CC1	46..518	CDD:273721	63/261 (24%)
		Interaction with JUN. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..406		19/95 (20%)
		Activating domain. /evidence=ECO:0000250|UniProtKB:Q8VH51	291..355		13/65 (20%)
		Interaction with ESR1 and ESR2. /evidence=ECO:0000250|UniProtKB:Q8VH51	355..406		6/29 (21%)
		Interaction with NCOA6. /evidence=ECO:0000250|UniProtKB:Q8VH51	406..530