DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rb97D and Hnrnpa2b1

DIOPT Version :9

Sequence 1:	NP_001014671.1	Gene:	Rb97D / 43231	FlyBaseID:	FBgn0004903	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001361674.1	Gene:	Hnrnpa2b1 / 53379	MGIID:	104819	Length:	353	Species:	Mus musculus

Alignment Length:	450	Identity:	142/450 - (31%)
Similarity:	200/450 - (44%)	Gaps:	119/450 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLMVDRAQE 91
            |.|..||||||||:..||||:|:.:|.||||:.|.|||||.|:||||||||:|::....||.|..
Mouse    16 EKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMA 80

  Fly    92 NRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLT 156
            .|||.|||:.||.|||:.|.|......:::||||||||:|::.:|..||:||.::|.:.:::::|
Mouse    81 ARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIIT 145

  Fly   157 DKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQP----GGLANAI 217
            |:.:||:|||.||.|||:|.|||.:|:|.|.|...:.:|:|::...:.:|.|..    ||....
Mouse   146 DRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGF- 209

  Fly   218 KPSLNQQQQQQGGGQQPPNGNMQAPSFRPPVPPQQAMGPYQQQPPPAPMSAPPPNFNYWGPPPPA 282
                   ...:|||     ||.                            .|.|..|:.|    .
Mouse   210 -------GDSRGGG-----GNF----------------------------GPGPGSNFRG----G 230

  Fly   283 MPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCPPPVQQVPPVGAVPPPMG 347
            ...|      ....|:|       :|:|.....|.|     .|..|.|                |
Mouse   231 SDGY------GSGRGFG-------DGYNGYGGGPGG-----GNFGGSP----------------G 261

  Fly   348 HNGPPPTAPGNWNMPPPVPGAAPPSHQQQSSQQPTPQPNFGTGYQQNYGGGPSKHNNMNANRMNP 412
            :.|    ..|.:       |...|.:..|..       .:|.|| .|||||             .
Mouse   262 YGG----GRGGY-------GGGGPGYGNQGG-------GYGGGY-DNYGGG-------------N 294

  Fly   413 YSAGPPNSY--HTPQPPAYTGYNAGPLPPNGSVPPPTGAKAVGVSNGSVATGG-SANSKY 469
            |.:|..|.:  :..||..|....:|....:.::..|.|....| ..||..:|| ...|:|
Mouse   295 YGSGSYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYG-PGGSGGSGGYGGRSRY 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_001014671.1	RRM1_hnRNPA_like	33..110	CDD:241022	47/76 (62%)
Rb97D	NP_001014671.1	RRM2_hnRNPA_like	124..196	CDD:240774	33/71 (46%)
Hnrnpa2b1	NP_001361674.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	48/79 (61%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	36/78 (46%)
		Disordered. /evidence=ECO:0000250\|UniProtKB:P22626	193..353		52/271 (19%)
		HnRNPA1	302..326	CDD:402981	4/23 (17%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		10/39 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8158
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S742
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2767
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.760