DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rb97D and Hnrnpa3

DIOPT Version :9

Sequence 1:	NP_001014671.1	Gene:	Rb97D / 43231	FlyBaseID:	FBgn0004903	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001104764.1	Gene:	Hnrnpa3 / 362152	RGDID:	727807	Length:	379	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	139/463 - (30%)
Similarity:	197/463 - (42%)	Gaps:	120/463 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EEDDICELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLM 85
            |..|..|.|.|||||||||:..||:::|:..:.:||.:.|.|||||..|||||||||:||:....
  Rat    24 EGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEE 88

  Fly    86 VDRAQENRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVV 150
            ||.|...|||.:||:.||.|||:.|.:......:::|||:||||:|::.:|..||:||.::|.:.
  Rat    89 VDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIE 153

  Fly   151 SVKLLTDKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLAN 215
            :::::.|:.:||:||||||.|||:|.|||.:::|.|.|...:.:|||:   |.|:|.|..|
  Rat   154 TIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKA---LSKQEMQSAG---- 211

  Fly   216 AIKPSLNQQQQQQGGGQQPPNGNMQAPSFRPPVPPQQAMGPYQQQPPPAPMSAPPPNFNYWGPPP 280
                    .|:.:|||    :||.....                    ........||...|
  Rat   212 --------SQRGRGGG----SGNFMGRG--------------------GNFGGGGGNFGRGG--- 241

  Fly   281 PAMPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCPPPVQQVPPVGAVPPP 345
                         ...|.|.|     .|.........|......|.:|..
  Rat   242 -------------NFGGRGGY-----GGGGGGSRGSYGGGDGGYNGFGGD--------------- 273

  Fly   346 MGHN---GPPPTAPGNWNMPPPVPGAAPPSHQQQSS---------QQPTPQPNFGTGYQQNYGGG 398
             |.|   ||..::.|.:       |...|.:..|..         .......|||.|   |||||
  Rat   274 -GGNYGGGPGYSSRGGY-------GGGGPGYGNQGGGYGGGGGGYDGYNEGGNFGGG---NYGGG 327

  Fly   399 PSKHNNMNANRMNPYSAGPPNSYHTPQPPAYTGYNAGPLPPNGSVPPPTGAKAVGVSNGSVATGG 463
            .      |.|....||....::|...:..::.|.::|         .|.|.   |..:|    ||
  Rat   328 G------NYNDFGNYSGQQQSNYGPMKGGSFGGRSSG---------SPYGG---GYGSG----GG 370

  Fly   464 SANSKYRR 471
            |.....||
  Rat   371 SGGYGSRR 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_001014671.1	RRM1_hnRNPA_like	33..110	CDD:241022	42/76 (55%)
Rb97D	NP_001014671.1	RRM2_hnRNPA_like	124..196	CDD:240774	31/71 (44%)
Hnrnpa3	NP_001104764.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		4/10 (40%)
		RRM1_hnRNPA_like	36..113	CDD:409992	42/76 (55%)
		RRM2_hnRNPA3	126..205	CDD:409996	36/81 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		10/36 (28%)
		HnRNPA1	332..>348	CDD:402981	3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..379		14/60 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I8203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920