Protein Alignment Rb97D and HNRNPA2B1

DIOPT Version :10

• Sequence 1: NP_524520.1
• Gene: Rb97D / 43231
• FlyBaseID: FBgn0004903
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_112533.1
• Gene: HNRNPA2B1 / 3181
• HGNCID: 5033
• Length: 353
• Species: Homo sapiens
• Alignment Length: 458
• Identity: 145/458 - (31%)
• Similarity: 199/458 - (43%)
• Gaps: 135/458 - (29%)

  Fly    27 ELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLMVDRAQE 91
            |.|..||||||||:..||||:|:.:|.||||:.|.|||||.|:||||||||:|::....||.|..
Human    16 EKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMA 80

  Fly    92 NRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLT 156
            .|||.|||:.||.|||:.|.|......:::||||||||:|::.:|..||:||.::|.:.:::::|
Human    81 ARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIIT 145

  Fly   157 DKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQP----GGLANAI 217
            |:.:||:|||.||.|||:|.|||.:|:|.|.|...:.:|:|::...:.:|.|..    ||....
Human   146 DRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGF- 209

  Fly   218 KPSLNQQQQQQGGGQQPPNGNMQAPSFRPPVPPQQAMGPYQQQPPPAPMSAPPPNFNYWGPPPPA 282
                   ...:|||     ||.                            .|.|..|:.|    .
Human   210 -------GDSRGGG-----GNF----------------------------GPGPGSNFRG----G 230

  Fly   283 MPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCPPPVQQVPPVGAVPPPMG 347
            ...|      ....|:|       :|:|.....|.|     .|..|.|                |
Human   231 SDGY------GSGRGFG-------DGYNGYGGGPGG-----GNFGGSP----------------G 261

  Fly   348 HNGPPPTAPGNWNMPPPVPGAAPPSHQQQSSQQPTPQPNFGTGYQQNYGGGPSKHNNMNANRMNP 412
            :.|    ..|.:       |...|.:..|..       .:|.|| .|||||  .:.:.|.|....
Human   262 YGG----GRGGY-------GGGGPGYGNQGG-------GYGGGY-DNYGGG--NYGSGNYNDFGN 305

  Fly   413 YSAGPPNSYHTPQPPA-----------YTGYNAGPLPPNGSVPPPTGAKAVGVSNGSVATGGSAN 466
            |:..|.|  :.|....           |.|.|.||                |.|.||...||  .
Human   306 YNQQPSN--YGPMKSGNFGGSRNMGGPYGGGNYGP----------------GGSGGSGGYGG--R 350

  Fly   467 SKY 469
            |:|
Human   351 SRY 353

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_524520.1	RRM2_hnRNPA_like	124..196	CDD:409766	33/71 (46%)
		RRM_SF	33..110	CDD:473069	47/76 (62%)
HNRNPA2B1	NP_112533.1	Nuclear localization signal. /evidence=ECO:0000255	9..15
		RRM1_hnRNPA2B1	19..99	CDD:410155	48/79 (61%)
		RRM2_hnRNPA2B1	112..191	CDD:409995	36/78 (46%)
		Disordered. /evidence=ECO:0000269|PubMed:26544936	193..353		55/279 (20%)
		HnRNPA1	302..326	CDD:463312	4/25 (16%)
		Nuclear targeting sequence. /evidence=ECO:0000250	308..347		12/56 (21%)