Protein Alignment Rb97D and HNRNPA1

DIOPT Version :10

• Sequence 1: NP_524520.1
• Gene: Rb97D / 43231
• FlyBaseID: FBgn0004903
• Length: 471
• Species: Drosophila melanogaster
• Sequence 2: NP_112420.1
• Gene: HNRNPA1 / 3178
• HGNCID: 5031
• Length: 372
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 134/470 - (28%)
• Similarity: 199/470 - (42%)
• Gaps: 139/470 - (29%)

  Fly    27 ELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLMVDRAQE 91
            |.|.|||||||||:..||:|:|:..:.|||.:.|.|||||..|||||||||:||.....||.|..
Human     9 EPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMN 73

  Fly    92 NRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLT 156
            .|||.:||:.||.|||:.|.:.:....:::|||:||||:|::.:|..||:||.|:|.:..::::|
Human    74 ARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMT 138

  Fly   157 DKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLANAIKPSL 221
            |:.:||:||||||.|||:|:|||.:::|.|.:...:.:|:|:   |.|:|      :|:|    .
Human   139 DRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA---LSKQE------MASA----S 190

  Fly   222 NQQQQQQG--------GGQQPPNGNMQAPSFRPPVPPQQAMGPYQQQPPPAPMSAPPPNFN---- 274
            :.|:.:.|        ||....|.|.....                            ||:
Human   191 SSQRGRSGSGNFGGGRGGGFGGNDNFGRGG----------------------------NFSGRGG 227

  Fly   275 ---------YWGPPPPAMPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCP 330
                     |.|             .....||:|     ...|:....|...|..:.:
Human   228 FGGSRGGGGYGG-------------SGDGYNGFG-----NDGGYGGGGPGYSGGSRGY------- 267

  Fly   331 PPVQQVPPVGAVPPPMGHNGPPPTAPGNWNMPPPVPGAAPPSHQQQSSQQPTPQPNFGTGYQQNY 395
                     |:.....|:.|......|:::                 |........||.|...|:
Human   268 ---------GSGGQGYGNQGSGYGGSGSYD-----------------SYNNGGGGGFGGGSGSNF 306

  Fly   396 GGGPS-----KHNNMNANRMNPYSAGPPNSYHTPQPPAYTGYNAGPLPPNGS-VPPPTGAKAVGV 454
            |||.|     .:||.::| ..|...|           .:.|.::||....|. ...|......|
Human   307 GGGGSYNDFGNYNNQSSN-FGPMKGG-----------NFGGRSSGPYGGGGQYFAKPRNQGGYG- 358

  Fly   455 SNGSVATGGSANSKY 469
                   |.|::|.|
Human   359 -------GSSSSSSY 366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_524520.1	RRM2_hnRNPA_like	124..196	CDD:409766	32/71 (45%)
		RRM_SF	33..110	CDD:473069	44/76 (58%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		49/84 (58%)
		RRM1_hnRNPA1	12..92	CDD:410154	46/79 (58%)
		Globular B domain	95..185		38/92 (41%)
		RRM2_hnRNPA3	105..184	CDD:409996	36/81 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	182..216		9/43 (21%)
		RNA-binding RGG-box	218..240		4/62 (6%)
		HnRNPA1	312..344	CDD:463312	8/43 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	317..372		15/70 (21%)
		Nuclear targeting sequence (M9)	320..357		9/48 (19%)