DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rb97D and HNRNPA1

DIOPT Version :9

Sequence 1:	NP_001014671.1	Gene:	Rb97D / 43231	FlyBaseID:	FBgn0004903	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_112420.1	Gene:	HNRNPA1 / 3178	HGNCID:	5031	Length:	372	Species:	Homo sapiens

Alignment Length:	470	Identity:	134/470 - (28%)
Similarity:	199/470 - (42%)	Gaps:	139/470 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 ELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLMVDRAQE 91
            |.|.|||||||||:..||:|:|:..:.|||.:.|.|||||..|||||||||:||.....||.|..
Human     9 EPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMN 73

  Fly    92 NRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVVSVKLLT 156
            .|||.:||:.||.|||:.|.:.:....:::|||:||||:|::.:|..||:||.|:|.:..::::|
Human    74 ARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMT 138

  Fly   157 DKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLANAIKPSL 221
            |:.:||:||||||.|||:|:|||.:::|.|.:...:.:|:|:   |.|:|      :|:|    .
Human   139 DRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKA---LSKQE------MASA----S 190

  Fly   222 NQQQQQQG--------GGQQPPNGNMQAPSFRPPVPPQQAMGPYQQQPPPAPMSAPPPNFN---- 274
            :.|:.:.|        ||....|.|.....                            ||:
Human   191 SSQRGRSGSGNFGGGRGGGFGGNDNFGRGG----------------------------NFSGRGG 227

  Fly   275 ---------YWGPPPPAMPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCP 330
                     |.|             .....||:|     ...|:....|...|..:.:
Human   228 FGGSRGGGGYGG-------------SGDGYNGFG-----NDGGYGGGGPGYSGGSRGY------- 267

  Fly   331 PPVQQVPPVGAVPPPMGHNGPPPTAPGNWNMPPPVPGAAPPSHQQQSSQQPTPQPNFGTGYQQNY 395
                     |:.....|:.|......|:::                 |........||.|...|:
Human   268 ---------GSGGQGYGNQGSGYGGSGSYD-----------------SYNNGGGGGFGGGSGSNF 306

  Fly   396 GGGPS-----KHNNMNANRMNPYSAGPPNSYHTPQPPAYTGYNAGPLPPNGS-VPPPTGAKAVGV 454
            |||.|     .:||.::| ..|...|           .:.|.::||....|. ...|......|
Human   307 GGGGSYNDFGNYNNQSSN-FGPMKGG-----------NFGGRSSGPYGGGGQYFAKPRNQGGYG- 358

  Fly   455 SNGSVATGGSANSKY 469
                   |.|::|.|
Human   359 -------GSSSSSSY 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_001014671.1	RRM1_hnRNPA_like	33..110	CDD:241022	44/76 (58%)
Rb97D	NP_001014671.1	RRM2_hnRNPA_like	124..196	CDD:240774	32/71 (45%)
HNRNPA1	NP_112420.1	Globular A domain	4..94		49/84 (58%)
		RRM1_hnRNPA1	12..92	CDD:410154	46/79 (58%)
		Globular B domain	95..185		38/92 (41%)
		RRM2_hnRNPA3	105..184	CDD:409996	36/81 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	182..216		9/43 (21%)
		RNA-binding RGG-box	218..240		4/62 (6%)
		HnRNPA1	307..344	CDD:402981	12/48 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..372		15/70 (21%)
		Nuclear targeting sequence (M9)	320..357		9/48 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8155
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820