DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Rb97D and HNRNPA3

DIOPT Version :9

Sequence 1:	NP_001014671.1	Gene:	Rb97D / 43231	FlyBaseID:	FBgn0004903	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_001317178.1	Gene:	HNRNPA3 / 220988	HGNCID:	24941	Length:	378	Species:	Homo sapiens

Alignment Length:	461	Identity:	139/461 - (30%)
Similarity:	199/461 - (43%)	Gaps:	117/461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 EEDDICELEHLRKLFIGGLAPYTTEENLKLFYGQWGKVVDVVVMRDAATKRSRGFGFITYTKSLM 85
            |..|..|.|.|||||||||:..||:::|:..:.:||.:.|.|||||..|||||||||:||:....
Human    24 EGHDPKEPEQLRKLFIGGLSFETTDDSLREHFEKWGTLTDCVVMRDPQTKRSRGFGFVTYSCVEE 88

  Fly    86 VDRAQENRPHIIDGKTVEAKRALPRPERESRETNISVKKLFVGGLKDNHDEECLREYFLQFGNVV 150
            ||.|...|||.:||:.||.|||:.|.:......:::|||:||||:|::.:|..||:||.::|.:.
Human    89 VDAAMCARPHKVDGRVVEPKRAVSREDSVKPGAHLTVKKIFVGGIKEDTEEYNLRDYFEKYGKIE 153

  Fly   151 SVKLLTDKTTGKRRGFAFVEFDDYDAVDKAILKKQHAIKYVHVDVKKSIYNLDKKEKQQPGGLAN 215
            :::::.|:.:||:||||||.|||:|.|||.:::|.|.|...:.:|||:   |.|:|.|..|
Human   154 TIEVMEDRQSGKKRGFAFVTFDDHDTVDKIVVQKYHTINGHNCEVKKA---LSKQEMQSAG---- 211

  Fly   216 AIKPSLNQQQQQQGGGQQPPNGNMQAPSFRPPVPPQQAMGPYQQQPPPAPMSAPPPNF------- 273
                    .|:.:|||    :||.....                    ........||
Human   212 --------SQRGRGGG----SGNFMGRG--------------------GNFGGGGGNFGRGGNFG 244

  Fly   274 ---NYWGPPPPAMPPYYQQPPPQQMNGWGPYPPPQQNGWNAPPPPPPGAQQWHANQWGCPPPVQQ 335
               .|.|....:...|        ..|.|.|     ||:..           ....:|..|....
Human   245 GRGGYGGGGGGSRGSY--------GGGDGGY-----NGFGG-----------DGGNYGGGPGYSS 285

  Fly   336 VPPVGAVPPPMGHNGPPPTAPGNWNMPPPVPGAAPPSHQQQSSQQPTPQPNFGTGYQQNYGGGPS 400
            ....|...|..|:.|      |.:.     .|.....:.:..        |||.|   |||||.
Human   286 RGGYGGGGPGYGNQG------GGYG-----GGGGYDGYNEGG--------NFGGG---NYGGGG- 327

  Fly   401 KHNNMNANRMNPYSAGPPNSYHTPQPPAYTGYNAGPLPPNGSVPPPTGAKAVGVSNGSVATGGSA 465
                 |.|....||....::|...:..::.|.::|         .|.|.   |..:|    |||.
Human   328 -----NYNDFGNYSGQQQSNYGPMKGGSFGGRSSG---------SPYGG---GYGSG----GGSG 371

  Fly   466 NSKYRR 471
            ....||
Human   372 GYGSRR 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rb97D	NP_001014671.1	RRM1_hnRNPA_like	33..110	CDD:241022	42/76 (55%)
Rb97D	NP_001014671.1	RRM2_hnRNPA_like	124..196	CDD:240774	31/71 (44%)
HNRNPA3	NP_001317178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35		4/10 (40%)
		RRM1_hnRNPA_like	36..113	CDD:409992	42/76 (55%)
		RRM2_hnRNPA3	126..205	CDD:409996	36/81 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	204..225		10/36 (28%)
		HnRNPA1	331..>347	CDD:402981	3/15 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	336..378		13/58 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	85	1.000	Domainoid score	I8155
eggNOG	1	0.900	-	-		E33208_3BA81
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1202220at2759
OrthoFinder	1	1.000	-	-		FOG0000779
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X431
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820