DRSC/TRiP Functional Genomics Resources

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Protein Alignment SPARC and SPARCL1

DIOPT Version :9

Sequence 1:NP_001262998.1 Gene:SPARC / 43230 FlyBaseID:FBgn0026562 Length:304 Species:Drosophila melanogaster
Sequence 2:NP_001121782.1 Gene:SPARCL1 / 8404 HGNCID:11220 Length:664 Species:Homo sapiens


Alignment Length:291 Identity:91/291 - (31%)
Similarity:129/291 - (44%) Gaps:57/291 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LRLLEEKNKIKDIERENEIATKLAEVQ-----HNLLNP----------VVEVDLCETMSCGAGRI 95
            |::.|::.|:.  |.||...|:..|.|     .|..|.          |..||.|.:..|..|.|
Human   381 LKIEEQREKVH--ENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDSCMSFQCKRGHI 443

  Fly    96 CQMHDE-KPKCVCIP--ECPEEVDTRRL--VCTNTNETWPSDCSVYQQRCWCDSGEPGCTNPDNA 155
            |:...: ||.|||..  .||   .|:.|  ||...|:|:.|.|.::..:|..:..:.|      .
Human   444 CKADQQGKPHCVCQDPVTCP---PTKPLDQVCGTDNQTYASSCHLFATKCRLEGTKKG------H 499

  Fly   156 HMHIDYYGACHEPRSCEGEDLKDFPRRMRDWLFNVMRDLAER---------------------DE 199
            .:.:||:|||....:|...::..||.||||||.|::..|.|.                     ||
Human   500 QLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDE 564

  Fly   200 ----LTEHYMQMELEAETNNSRRWSNAAVWKWCDLD-GDTDRSVSRHELFPIRAPLVSLEHCIAP 259
                ..:|.:.:.|.....|...:.....|::.:|| ...||.::..||.|:||.||.:||||..
Human   565 KRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCITR 629

  Fly   260 FLESCDSNKDHRITLVEWGACLELDPEDLKE 290
            |.|.||.|||..|||.|||.|..:..||:.|
Human   630 FFEECDPNKDKHITLKEWGHCFGIKEEDIDE 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
SPARCNP_001262998.1 FSL_SPARC 85..168 CDD:238649 27/87 (31%)
SPARC_Ca_bdg 169..278 CDD:287550 44/134 (33%)
SPARC_EC 170..292 CDD:238155 50/147 (34%)
SPARCL1NP_001121782.1 O-glycosylated at one additional site 25..34
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..360
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..426 9/39 (23%)
KAZAL_FS 433..512 CDD:294071 27/87 (31%)
SPARC_Ca_bdg 513..648 CDD:287550 44/134 (33%)
SPARC_EC 514..662 CDD:238155 50/147 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158950
Domainoid 1 1.000 76 1.000 Domainoid score I8965
eggNOG 1 0.900 - - E1_KOG4004
Hieranoid 00.000 Not matched by this tool.
Homologene 1 1.000 - - H3438
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1528521at2759
OrthoFinder 1 1.000 - - FOG0003487
OrthoInspector 1 1.000 - - otm41261
orthoMCL 1 0.900 - - OOG6_105759
Panther 1 1.100 - - LDO PTHR13866
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2812
SonicParanoid 1 1.000 - - X2378
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.740

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