DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPARC and SPOCK1

DIOPT Version :9

Sequence 1:	NP_001262998.1	Gene:	SPARC / 43230	FlyBaseID:	FBgn0026562	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_004589.1	Gene:	SPOCK1 / 6695	HGNCID:	11251	Length:	439	Species:	Homo sapiens

Alignment Length:	305	Identity:	64/305 - (20%)
Similarity:	110/305 - (36%)	Gaps:	84/305 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DLLDEDLDLSDIDENEEEFLRLLEEKNKIKDIER-ENEIATKLAEVQHNLLNPVVEVDLCETMSC 90
            :.||.|..||.:.:.:.:     :..|:.:|.:. .|....|..:   ..|:|  ..|.|..:.|
Human    37 NFLDNDQWLSTVSQYDRD-----KYWNRFRDDDYFRNWNPNKPFD---QALDP--SKDPCLKVKC 91

  Fly    91 GAGRICQMHD-EKPKCV---------------------------CIPECPEEVDTRRLVCTNTNE 127
            ...::|...| :...||                           |.| ||  |....:||.:...
Human    92 SPHKVCVTQDYQTALCVSRKHLLPRQKKGNVAQKHWVGPSNLVKCKP-CP--VAQSAMVCGSDGH 153

  Fly   128 TWPSDCSVYQQRC--------WCDSGEPGCTNPDNAHMHIDYYGACH--EPRSCEGEDLKDFPRR 182
            ::.|.|.:....|        .||...|....|:...         |  |..:|..::|::...|
Human   154 SYTSKCKLEFHACSTGKSLATLCDGPCPCLPEPEPPK---------HKAERSACTDKELRNLASR 209

  Fly   183 MRDWLFNVMRDLAERDELTEHYMQMELEAETNNSR--RWSNAAV--------WKWCDLDGDTDRS 237
            ::|| |..:.:.|.|          .::..::|:.  |:..:.:        |.:..||.:.|..
Human   210 LKDW-FGALHEDANR----------VIKPTSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLL 263

  Fly   238 VSRHELFPIRAPLVSLEHCIAPFLESCDSNKDHRITLVEWGACLE 282
            :...|:..|.  |...|.||.|...||||.||.:::..||..|.:
Human   264 LDPSEINAIY--LDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQ 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPARC	NP_001262998.1	FSL_SPARC	85..168	CDD:238649	21/120 (18%)
		SPARC_Ca_bdg	169..278	CDD:287550	28/118 (24%)
		SPARC_EC	170..292	CDD:238155	30/123 (24%)
SPOCK1	NP_004589.1	Kazal_2	139..178	CDD:284958	9/40 (23%)
		SPARC_Ca_bdg	196..302	CDD:287550	28/118 (24%)
		SPARC_EC	197..315	CDD:238155	30/123 (24%)
		TY	312..372	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910