DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPARC and sparc

DIOPT Version :9

Sequence 1:	NP_001262998.1	Gene:	SPARC / 43230	FlyBaseID:	FBgn0026562	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	NP_001001942.1	Gene:	sparc / 321357	ZFINID:	ZDB-GENE-030131-9	Length:	291	Species:	Danio rerio

Alignment Length:	317	Identity:	91/317 - (28%)
Similarity:	139/317 - (43%)	Gaps:	66/317 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LWLLLGLGLLAVSHVQASTEFSEDLLDEDLD--LSDIDENEEEFLRLLEEKNKIKDIERENEIAT 66
            :|:.. |..||...:.|.|| .|..::|:|:  ::.:.....||...:|   .::|:..||.
Zfish     3 VWIFF-LFCLAGKTLAAPTE-EEPAVEEELEVGINPVQVETGEFDEAIE---VVEDVIAENP--- 59

  Fly    67 KLAEVQHNLLNPVVEVDLCETMSCGAGRICQMHD-EKPKCVCIP--ECPEEVDTRRLVCTNTNET 128
                              |....|..|::|::.| .:|.|||..  .||..:.....||...|:|
Zfish    60 ------------------CLNHHCKKGKVCEVDDSNQPMCVCQDPLTCPAPIGDFEHVCGTNNKT 106

  Fly   129 WPSDCSVYQQRCWCDSGEPGCTNPDNAH-MHIDYYGACHEPRSCEGEDLKDFPRRMRDWLFNVMR 192
            :.|.|..:..:|..:..:.|       | :||||.|.|.....|...:|.:||.||||||.||:.
Zfish   107 YESSCHFFATKCSLEGTKKG-------HKLHIDYIGPCKYIAPCLENELNEFPLRMRDWLKNVLV 164

  Fly   193 DLAERDE----LTEHYMQMELEAETNNSRRWS-----------------NAAV----WKWCDLD- 231
            .|.||||    |||. .::.::....|.:|..                 |..:    |::..||
Zfish   165 TLYERDEDNNLLTEK-QKLRVKKIYENEKRLQAGDHSLDLLALDFEKNYNMYIFPVHWQFGQLDQ 228

  Fly   232 GDTDRSVSRHELFPIRAPLVSLEHCIAPFLESCDSNKDHRITLVEWGACLELDPEDL 288
            ...|..:|..||.|:||||:.:|||...|.|.||:::|..|.|.||..|..:..:|:
Zfish   229 HPIDGFLSHTELAPLRAPLIPMEHCTTSFFEQCDADQDKYIALEEWANCFGIKEQDV 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPARC	NP_001262998.1	FSL_SPARC	85..168	CDD:238649	26/86 (30%)
		SPARC_Ca_bdg	169..278	CDD:287550	46/134 (34%)
		SPARC_EC	170..292	CDD:238155	49/145 (34%)
sparc	NP_001001942.1	FSL_SPARC	59..140	CDD:238649	26/108 (24%)
		SPARC_EC	142..289	CDD:238155	49/145 (34%)
		SPARC_Ca_bdg	142..275	CDD:287550	46/133 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594917
Domainoid	1	1.000	73	1.000	Domainoid score	I9203
eggNOG	1	0.900	-	-		E1_KOG4004
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	119	1.000	Inparanoid score	I4765
OMA	1	1.010	-	-		QHG46414
OrthoDB	1	1.010	-	-		D1528521at2759
OrthoFinder	1	1.000	-	-		FOG0003487
OrthoInspector	1	1.000	-	-		otm26401
orthoMCL	1	0.900	-	-		OOG6_105759
Panther	1	1.100	-	-	O	PTHR13866
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2812
SonicParanoid	1	1.000	-	-		X2378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800