DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPARC and Spock1

DIOPT Version :9

Sequence 1:	NP_001262998.1	Gene:	SPARC / 43230	FlyBaseID:	FBgn0026562	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	XP_038951544.1	Gene:	Spock1 / 306759	RGDID:	1311496	Length:	444	Species:	Rattus norvegicus

Alignment Length:	319	Identity:	67/319 - (21%)
Similarity:	107/319 - (33%)	Gaps:	107/319 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DLLDEDLDLSDI-------------DENEEEFLRLLEEKNKIKDIERENEIATKLAEVQHNLLNP 78
            :.||.|..||.:             ||.|:::.|   ..|..|..::              .|:|
  Rat    37 NFLDNDQWLSTVSQYDRDKYWNRFRDEVEDDYFR---NWNPNKPFDQ--------------ALDP 84

  Fly    79 VVEVDLCETMSCGAGRICQMHD-EKPKCV---------------------------CIPECPEEV 115
              ..|.|..:.|...::|...| :...||                           |.| ||  |
  Rat    85 --SKDPCLKVKCSPHKVCVTQDYQTALCVSRKHLLPRQKKGSVAHKHWVGPSNLVKCKP-CP--V 144

  Fly   116 DTRRLVCTNTNETWPSDCSVYQQRC--------WCDSGEPGCTNPDNAHMHIDYYGACHEPR--- 169
            ....:||.:...|:.|.|.:....|        .||...|....|:            .||:
  Rat   145 AQSAMVCGSDGHTYTSKCKLEFHACSTGKSLSSLCDGPCPCLPEPE------------PEPQKPK 197

  Fly   170 ----SCEGEDLKDFPRRMRDWLFNVMRDLAERDELTEHYMQMELEAETNNSR-------RWSNAA 223
                :|..::|::...|::|| |..:.:.|.|       :.....::|...|       ...::.
  Rat   198 AEKSACTDKELRNLASRLKDW-FGALHEDANR-------VIKPTSSDTTQGRFDTSILPICKDSL 254

  Fly   224 VWKWCDLDGDTDRSVSRHELFPIRAPLVSLEHCIAPFLESCDSNKDHRITLVEWGACLE 282
            .|.:..||.:.|..:...|:..|.  |...|.||.|...||||.||.:::..||..|.:
  Rat   255 GWMFNKLDMNYDLLLDHSEINAIY--LDKYEPCIKPLFNSCDSFKDGKLSNNEWCYCFQ 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPARC	NP_001262998.1	FSL_SPARC	85..168	CDD:238649	21/118 (18%)
		SPARC_Ca_bdg	169..278	CDD:287550	28/122 (23%)
		SPARC_EC	170..292	CDD:238155	30/120 (25%)
Spock1	XP_038951544.1	Kazal_2	139..>176	CDD:400135	11/39 (28%)
		EFh_SPARC_EC	203..314	CDD:330171	30/119 (25%)
		EF-hand motif	250..281	CDD:320009	7/32 (22%)
		EF-hand motif	282..314	CDD:320009	13/30 (43%)
		TY	317..378	CDD:238114
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910