DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPARC and spock1

DIOPT Version :9

Sequence 1:	NP_001262998.1	Gene:	SPARC / 43230	FlyBaseID:	FBgn0026562	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	XP_021336759.1	Gene:	spock1 / 110440200	ZFINID:	ZDB-GENE-110428-1	Length:	454	Species:	Danio rerio

Alignment Length:	333	Identity:	81/333 - (24%)
Similarity:	121/333 - (36%)	Gaps:	65/333 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRSLWLLLGLGLLAVSHVQASTEFSEDLLDEDLDLSDIDE----------NEEEFLRLLEEKNKI 55
            |.||.|.:.|..|.|| |..|::.:.  ||.|..:|.:.:          .::::.|.. ..||.
Zfish     2 MLSLGLFVSLVGLTVS-VTGSSDGNP--LDNDKWMSTVSQYDKSKYWNKFRDDDYFRTW-NPNKA 62

  Fly    56 KDIERENEIATKLAEVQHNLLNPVV------EVDLCETMSCGAGRICQMHD--------EKP--- 103
            :|.|......|:|....|:......      ..|.|..:.|...::|..||        .||
Zfish    63 QDQEHAPNQRTELNHKSHSKTKSRTTDGLDSTKDPCMKVHCPPHKVCVSHDYQTAICTNHKPAQH 127

  Fly   104 ---------------------KCVCIPECPEEVDTRRLVCTNTNETWPSDCSVYQQRCWCDSGE- 146
                                 ||   ..||  |....|||.:...|:.|.|.:..|.  |.||:
Zfish   128 SVKAKKGNIPHKRWMGAVNHGKC---RPCP--VVHSSLVCGSDGHTYASKCKLEFQA--CSSGKS 185

  Fly   147 --PGCTNPDNAHMHIDYYGACHEPRSCEGEDLKDFPRRMRDWLFNVMRDLAERDELTEHYMQMEL 209
              ..|..|.......:......|...|...||:....|::|| |.|:...|.||..|......:.
Zfish   186 LSAKCEGPCPCLPGQEVIKPHTEKNGCTDADLRSLASRLKDW-FGVLHTDANRDLKTSTSEAAQG 249

  Fly   210 EAETNNSRRWSNAAVWKWCDLDGDTDRSVSRHELFPIRAPLVSLEHCIAPFLESCDSNKDHRITL 274
            ..:|:......::..|.:..||.:.|..:.:.||..|.  |...|.|:.|...||||.||.:::.
Zfish   250 RFDTSILPICKDSLGWMFNKLDMNYDLLLDQSELSAIY--LDKYELCMRPLFNSCDSFKDGKLSN 312

  Fly   275 VEWGACLE 282
            .||..|.:
Zfish   313 NEWCYCFQ 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPARC	NP_001262998.1	FSL_SPARC	85..168	CDD:238649	24/117 (21%)
		SPARC_Ca_bdg	169..278	CDD:287550	31/108 (29%)
		SPARC_EC	170..292	CDD:238155	33/113 (29%)
spock1	XP_021336759.1	KAZAL	153..194	CDD:197624	14/44 (32%)
		EFh_SPARC_EC	212..323	CDD:330171	33/112 (29%)
		EF-hand motif	259..290	CDD:320009	8/32 (25%)
		EF-hand motif	291..321	CDD:320009	12/30 (40%)
		Thyroglobulin_1	327..390	CDD:306570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910