DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPARC and spock2

DIOPT Version :9

Sequence 1:	NP_001262998.1	Gene:	SPARC / 43230	FlyBaseID:	FBgn0026562	Length:	304	Species:	Drosophila melanogaster
Sequence 2:	XP_012821500.1	Gene:	spock2 / 100144943	XenbaseID:	XB-GENE-1003767	Length:	422	Species:	Xenopus tropicalis

Alignment Length:	372	Identity:	83/372 - (22%)
Similarity:	138/372 - (37%)	Gaps:	121/372 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLWLLLGLGLLAVSHVQA---STEFSEDLLDEDLDLSDI--------------DENEEEFLRLLE 50
            |..:||.| ||.::..|.   ..|.:.:.::::..||.|              ||.|:::::..|
Frog     7 SCLILLPL-LLPIAWAQGDGKEVENTGNFMEDEQWLSSINQYSGKIKHWNRFRDEVEDDYIKSWE 70

  Fly    51 EKNKIKDIERENEIATKLAEVQHNLLNPVVEVDLCETMSCGAGRICQMHDEKPKCVCIPE----- 110
            : |:..|   |....||               |.|:.:.|...::|..|..: |.:||..
Frog    71 D-NQPGD---EALDTTK---------------DPCQKVKCSRHKVCIAHGYQ-KAMCISRKKLEH 115

  Fly   111 ----------------C-PEEVDTRRLVCTNTNETWPSDCSVYQQRCWCDSGEPGCTNPDNAHMH 158
                            | |..|.....||.:...|:.|.|.:.||.|.           .:..:.
Frog   116 RIKQPSMKIHGNRDSLCKPCHVTQPAAVCGSDGHTYSSVCKLEQQACL-----------SSKQLT 169

  Fly   159 IDYYGAC-----HEP----------RSCEGEDLKDFPRRMRDWLFNVMRDLAERDELTE------ 202
            :...|:|     |.|          .:|.|:||.|...|:||| |.::.:.::::..:.
Frog   170 VKCQGSCPCPTEHTPTTTTETGKQGETCTGQDLADLGDRLRDW-FQLLHENSKQNNTSNPGSKQV 233

  Fly   203 HYMQMELEAETNNSRRWSNAAVWKWCDLDGDTDRSVSRHELFPIRAPLVSLEHCIAPFLESCDSN 267
            :.:...|.|...:|      ..|.:..||.:.|..:.:.||..|.  |...|.||.||..|||:.
Frog   234 NVLDKSLVAGCKDS------IGWMFSKLDSNNDLFLDQAELAAIN--LDKYEICIRPFFNSCDTY 290

  Fly   268 KDHRITLVEWGAC---------LELDPEDLKE-----------RCDD 294
            ||.|::..||..|         :||:...::|           .||:
Frog   291 KDGRVSTAEWCFCFWREKPPCLVELEKVQIQEAAKRKPGVFIPSCDE 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPARC	NP_001262998.1	FSL_SPARC	85..168	CDD:238649	21/109 (19%)
		SPARC_Ca_bdg	169..278	CDD:287550	33/114 (29%)
		SPARC_EC	170..292	CDD:238155	38/147 (26%)
spock2	XP_012821500.1	KAZAL	<143..176	CDD:197624	9/43 (21%)
		EFh_SPARC_TICN2	197..308	CDD:320017	35/119 (29%)
		EF-hand motif	244..275	CDD:320017	9/38 (24%)
		EF-hand motif	276..308	CDD:320017	14/31 (45%)
		TY	310..374	CDD:238114	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910