DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ball and VRK3

DIOPT Version :9

Sequence 1:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_057524.3	Gene:	VRK3 / 51231	HGNCID:	18996	Length:	474	Species:	Homo sapiens

Alignment Length:	378	Identity:	105/378 - (27%)
Similarity:	176/378 - (46%)	Gaps:	49/378 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PRVAKPKAAAPAKKVVSAKKA--------KSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGF 58
            |:|.:   .:|.|...|.:|.        :|::....|.:..|||.||.:..||::.........
Human   116 PQVTR---GSPQKTSCSPQKTRQSPQTLKRSRVTTSLEALPTGTVLTDKSGRQWKLKSFQTRDNQ 177

  Fly    59 GEIYAA-------CKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGM 116
            |.:|.|       |..|.:.....:|.:.. :|.||.|.:|:.|.||...:.::.:.:....|.:
Human   178 GILYEAAPTSTLTCDSGPQKQKFSLKLDAK-DGRLFNEQNFFQRAAKPLQVNKWKKLYSTPLLAI 241

  Fly   117 PYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKR-LPEGTVYRLAIQMLDVYQYMHSNGYV 180
            |..:..|   |:.:|:||:|:|..|..|...|:.:.|. |.|.:|.::|.::||..:::|.|.||
Human   242 PTCMGFG---VHQDKYRFLVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYV 303

  Fly   181 HADLKAANILLGLEKGGAAQAYLVDFGLA-------SH--FVTGDFKPDPKKMHNGTIEYTSRDA 236
            |.::.|.||.:..|  ..:|..|..:|.|       .|  :|.|...|     |.|.:|:.|.|.
Human   304 HGNVTAENIFVDPE--DQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSP-----HEGDLEFISMDL 361

  Fly   237 HLGV-PTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKG-- 298
            |.|. |:||:||:.|||.:::||...|||.  ..|.....:.|.|:.|:|..|..:.   |.|
Human   362 HKGCGPSRRSDLQSLGYCMLKWLYGFLPWT--NCLPNTEDIMKQKQKFVDKPGPFVG---PCGHW 421

  Fly   299 VPP--PIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKP 349
            :.|  .:..::|.|..||:.::|.|...|:...:.|:.|::.....:...|.|
Human   422 IRPSETLQKYLKVVMALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	93/313 (30%)
		SPS1	47..432	CDD:223589	91/325 (28%)
		Pol_alpha_B_N	<399..>502	CDD:285602
VRK3	NP_057524.3	zinc_ribbon_2	4..26	CDD:289981
		DZR	5..>31	CDD:289539
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	41..152		8/38 (21%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14645249	49..64
		DUF4551	<82..>150	CDD:291746	7/36 (19%)
		PKc_like	155..457	CDD:304357	93/317 (29%)
		SPS1	211..>467	CDD:223589	81/270 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149476
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810