DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ball and vrk1

DIOPT Version :9

Sequence 1:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_998550.1	Gene:	vrk1 / 406694	ZFINID:	ZDB-GENE-040426-2709	Length:	425	Species:	Danio rerio

Alignment Length:	445	Identity:	169/445 - (37%)
Similarity:	249/445 - (55%)	Gaps:	40/445 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PAKKVVSAKKAKSKL-YKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACK--VGEKNYD 73
            |.||....|||::.. .|:.|:...|.|.||.||.:|::|.::|.||||.:|.|.:  .|....|
Zfish     2 PPKKADGVKKARAPAKRKLAEEFPSGEVLTDNAKKKWKLGSAVGQGGFGLLYLANEDSSGPVTAD 66

  Fly    74 A--VVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIV 136
            |  |:|.||..|||||.|:.||:|.||.:.|..:|:...::.||:|....:|..|.||:::||:|
Zfish    67 APYVIKVEPSDNGPLFSELKFYMRAAKPDLIGAWMKSKKMEYLGVPKYWGSGFHEKNGKRYRFMV 131

  Fly   137 MPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQA 201
            |.|:|:||.|..|.|||:.....|.:|.:::||:.:|:|.:.|||||:||:|:||......  |.
Zfish   132 MDRFGTDLQKLFEGNGKKFSRKLVLQLGLRLLDILEYIHDHEYVHADIKASNLLLSYTNPN--QV 194

  Fly   202 YLVDFGLASHF----VTGDFKPDPKKMHNGTIEYTSRDAHLGV-PTRRADLEILGYNLIEWLGAE 261
            :|||:|||..:    |..::|.|||:.|:||||:||.|||.|| |:|||||||:||.:|:||.:.
Zfish   195 FLVDYGLAYRYAPEGVPKEYKEDPKRCHDGTIEFTSIDAHKGVSPSRRADLEIMGYCMIQWLCSR 259

  Fly   262 LPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKG-VPPPIGDFMKYVSKLTHNQEPDYDKCR 325
            |||  :..|..|..|:.:|....|||.|.||:.|..| :|..:|.||:.|..|.:...|||||.|
Zfish   260 LPW--EDKLQDPLYVRDSKLRCRDNIDEFLKSCFASGNIPAEMGKFMQEVKVLGYTDRPDYDKLR 322

  Fly   326 SWFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSKAATARKAKKIDSPVLNSSLDEKISAS 390
            ......||.:...::..|||.:...::|..::..|...||                  :||..::
Zfish   323 GILQQGLKSIGSTDDKKLDFGVATNSTSLPSVKTPKRKKA------------------EEKGQSA 369

  Fly   391 EDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKR-----VADSSPPSQKRVKTEPK 440
            ::.:....|..|....|:|..:.:.|  ||.||     ...||.|:.|:.:..||
Zfish   370 DETDSTPAKKRRAPQKKEVNGAKKTA--SPAKRPVKKETQASSEPAVKKSRGRPK 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	135/301 (45%)
		SPS1	47..432	CDD:223589	152/399 (38%)
		Pol_alpha_B_N	<399..>502	CDD:285602	15/47 (32%)
vrk1	NP_998550.1	PKc_like	27..327	CDD:304357	135/303 (45%)
		SPS1	37..>265	CDD:223589	105/231 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..425		21/100 (21%)
		GAGA_bind	<373..>424	CDD:283799	15/52 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583607
Domainoid	1	1.000	155	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2970
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	1	1.000	-	-		FOG0002984
OrthoInspector	1	1.000	-	-		otm24694
orthoMCL	1	0.900	-	-		OOG6_106246
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4687
SonicParanoid	1	1.000	-	-		X1730
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.790