DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ball and vrk2

DIOPT Version :9

Sequence 1:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_957464.2	Gene:	vrk2 / 394145	ZFINID:	ZDB-GENE-040426-1046	Length:	574	Species:	Danio rerio

Alignment Length:	481	Identity:	172/481 - (35%)
Similarity:	238/481 - (49%)	Gaps:	65/481 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAACKVGEKNY------DAVVKCEPHGN 83
            |.|.:|..:.:|.:.||..|..||||..||.||||.||.|.:  :.|.      |.|:|.|.|.|
Zfish     4 KKYTLPRPLPDGCILTDSEKKNWRIGKMIGKGGFGLIYLASQ--DVNVPVRDDADFVIKVEYHEN 66

  Fly    84 GPLFVEMHFYLRNAKLEDIKQFMQKHGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFL 148
            ||||.|:.||.|.||.|.:.::|:...|..||:|....:|..|.||.::||:||.|.|:||.|.|
Zfish    67 GPLFSELKFYQRAAKPETMSKWMKSKQLGFLGIPTYWGSGLTESNGTRYRFMVMDRLGTDLQKVL 131

  Fly   149 EQNGKRLPEGTVYRLAIQMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHFV 213
            ..||.:|.:.:|.:|.:.||||.:|:|.|.|||||:||||:|||.....  :.||.|:||:..:.
Zfish   132 IDNGGQLRKTSVLQLGVLMLDVLEYIHDNEYVHADIKAANLLLGYRDPN--KVYLADYGLSYRYC 194

  Fly   214 TG----DFKPDPKKMHNGTIEYTSRDAHLGV-PTRRADLEILGYNLIEWLGAELPWVTQKLLAVP 273
            ..    ::|.:|||.|||||||||.|||.|| .:||.||::|||.|:.|....|||:..  |..|
Zfish   195 PNGEHKEYKENPKKGHNGTIEYTSIDAHKGVAASRRGDLKVLGYCLLHWQCGTLPWLPS--LKNP 257

  Fly   274 PKVQKAKEAFMDNIGESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIP 338
            .:||:||...|.|:.:|:..:........|..|:..|..|.:|::|||...|...|:...|
Zfish   258 AEVQEAKAKLMSNLPDSVLKMSTSSSSMEIAQFLSRVKDLGYNEKPDYQALRMVLSATGLQ---- 318

  Fly   339 NNGDLDFKMKPQTSSNNNLSPPGTSKAATARKA--KKI--DSPVLNSSLDEKISASEDDEEEEEK 399
              |.||...:..:.:..    |.|.:||:..|.  ||:  ..|.        ::|.|.|||:...
Zfish   319 --GPLDLSRQRASETVR----PTTQRAASQPKTTEKKMGRSKPA--------VTAEEIDEEQLGV 369

  Fly   400 SHRKKTAKKVTPSARNAKVSPLKRVADSSPPSQKRVKTEPKSTPRERATPKAS---------PKP 455
            |...|..:|..|...  |..|:            |..|..|.:.|:...|..|         |.|
Zfish   370 SSPNKVWRKTKPQTH--KQRPV------------RTDTAAKGSIRQNPMPCESDEDVSDEYEPLP 420

  Fly   456 RSTPKASPKPQTPTAARLRTPNAKIN 481
               |:..|:.:..|..|......|.|
Zfish   421 ---PRVHPRTRAGTRQRQELKQEKKN 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	131/302 (43%)
		SPS1	47..432	CDD:223589	151/399 (38%)
		Pol_alpha_B_N	<399..>502	CDD:285602	20/92 (22%)
vrk2	NP_957464.2	STKc_VRK2	13..313	CDD:271025	131/305 (43%)
vrk2	NP_957464.2	SPS1	25..406	CDD:223589	155/418 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583603
Domainoid	1	1.000	155	1.000	Domainoid score	I4177
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2970
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D371612at33208
OrthoFinder	1	1.000	-	-		FOG0002984
OrthoInspector	1	1.000	-	-		otm24694
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11909
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4687
SonicParanoid	1	1.000	-	-		X1730
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.890