DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ball and CSNK1E

DIOPT Version :9

Sequence 1:NP_651508.1 Gene:ball / 43228 FlyBaseID:FBgn0027889 Length:599 Species:Drosophila melanogaster
Sequence 2:NP_001885.1 Gene:CSNK1E / 1454 HGNCID:2453 Length:416 Species:Homo sapiens


Alignment Length:488 Identity:122/488 - (25%)
Similarity:187/488 - (38%) Gaps:101/488 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 QWRIGPSIGVGGFGEIYAACKVGEKNYDAV-VKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKH 109
            ::|:|..||.|.||:||....:......|: ::|....:..|.:|..||          :.||  
Human     8 KYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFY----------KMMQ-- 60

  Fly   110 GLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEGTVYRLAIQMLDVYQYM 174
              ..:|:|.|...|:   .|: :..:||...|..|........::....||..||.||:...:|:
Human    61 --GGVGIPSIKWCGA---EGD-YNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYI 119

  Fly   175 HSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHF---VTGDFKP-DPKKMHNGTIEYTSRD 235
            ||..::|.|:|..|.|:||.|.|.. .|::|||||..:   .|....| ...|...||..|.|.:
Human   120 HSKNFIHRDVKPDNFLMGLGKKGNL-VYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASIN 183

  Fly   236 AHLGV-PTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNIGESLKTLFPKGV 299
            .|||: .:||.|||.|||.|:.:....|||...|......|.::..|..|....|.|    .||.
Human   184 THLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVL----CKGY 244

  Fly   300 PPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKPQTSSNNNLSPPGTSK 364
            |.....::.:...|..:.:|||...|..|.:...:.....:...|:.|               .|
Human   245 PSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNM---------------LK 294

  Fly   365 AATARKAKKIDSPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSARNAKVSPLKRVADSSP 429
            ...||..:.:|            ....:.|.||.....:.:|.:..|               ..|
Human   295 FGAARNPEDVD------------RERREHEREERMGQLRGSATRALP---------------PGP 332

  Fly   430 P-----SQKRVKTEP-KSTPRERATPKASPKPRSTPKASPKPQTPTAARLRTPNAKINFSPSISL 488
            |     ::.|...|| .|||..|..|..:..||:..:..         |.|..:.:::       
Human   333 PTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVD---------RERKVSMRLH------- 381

  Fly   489 RGRPGGKTVINDDLTPQ------PRSKKTYEFN 515
            ||.|.  .|.:.|||.:      |.|:.:..|:
Human   382 RGAPA--NVSSSDLTGRQEVSRIPASQTSVPFD 412

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ballNP_651508.1 STKc_VRK 36..328 CDD:270917 86/287 (30%)
SPS1 47..432 CDD:223589 100/395 (25%)
Pol_alpha_B_N <399..>502 CDD:285602 20/108 (19%)
CSNK1ENP_001885.1 STKc_CK1_delta_epsilon 8..282 CDD:271027 87/296 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 301..416 30/157 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1164
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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