DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ball and Ttbk1

DIOPT Version :9

Sequence 1:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_001156336.1	Gene:	Ttbk1 / 106763	MGIID:	2147036	Length:	1308	Species:	Mus musculus

Alignment Length:	576	Identity:	136/576 - (23%)
Similarity:	231/576 - (40%)	Gaps:	124/576 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LAKGQWRIGPSIGVGGFGEIYAACKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFM 106
            :.|.:|::...||.|||||||.|..:..:. :..:|.|........::|       ::..:|:..
Mouse    29 VVKDRWKVLKKIGGGGFGEIYEAMDLLTRE-NVALKVESAQQPKQVLKM-------EVAVLKKLQ 85

  Fly   107 QK-HGLKSLGMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKRLPEG-----TVYRLAI 165
            .| |..:.:|..          ..||..::||...|.:|.......    |.|     |..||..
Mouse    86 GKDHVCRFIGCG----------RNEKFNYVVMQLQGRNLADLRRSQ----PRGTFTLSTTLRLGK 136

  Fly   166 QMLDVYQYMHSNGYVHADLKAANILLGLEKGGAAQAYLVDFGLASHF--VTGDFKPDPKKM--HN 226
            |:|:..:.:||.|::|.|:|.:|..:|.......:.|::|||||..:  .|||.:| |:.:  ..
Mouse   137 QILESIEAIHSVGFLHRDIKPSNFAMGRLPSTYRKCYMLDFGLARQYTNTTGDVRP-PRNVAGFR 200

  Fly   227 GTIEYTSRDAH----LGVPTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDNI 287
            ||:.|.|.:||    :|   |..||..|.|.|:|:...:|||   :.:....:|...||.:...
Mouse   201 GTVRYASVNAHKNREMG---RHDDLWSLFYMLVEFAVGQLPW---RKIKDKEQVGMIKEKYEHR- 258

  Fly   288 GESLKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKPQTS 352
                  :..|.:|.....|:.:::.|.:..:|||....|.|.:::|:..|..|...|:: |..|.
Mouse   259 ------MLLKHMPSEFHLFLDHIASLDYFTKPDYQLIMSVFENSMKERGIAENEAFDWE-KAGTD 316

  Fly   353 ---SNNNLSPPGTSKAATARKAKKID-SPVLNSSLDEKISASEDDEEEEEKSHRKKTAKKVTPSA 413
               |.:..:||..:...||.....:: :||....|.|.   :||..:.|..|. ::.|..:.|..
Mouse   317 ALLSTSTSTPPQQNTRQTAAMFGVVNVTPVPGDLLREN---TEDVLQGEHLSD-QENAPPILPGR 377

  Fly   414 RNAKV-----------SPLKRVADSSPPSQKRVKTEPKSTP---RERATPKASPKPRSTPKASPK 464
            ....:           .|...|.:.:..::.:::.....||   .|::.....|   |:|..:|
Mouse   378 PPEGLGPGPHLVPHPGGPEAEVWEETDVNRNKLRINIGKTPCVEEEQSRGVGVP---SSPVRAP- 438

  Fly   465 PQTPTAARLRTPNAKINFSPSISLRGRPGGKTVINDDLTPQPRSKKTYEFNFELDVSMDANVIVN 529
            |.:||             :|..||..|.     :|     .|.|::       |..:.|..|.:
Mouse   439 PDSPT-------------TPVRSLCYRR-----VN-----SPESER-------LSTAADGRVEL- 472

  Fly   530 VKRKKKADQDKATAVDSRTPSSRSALASSSKEEASPVTRVNLRKVNGHGDSSTPGR 585
                    |::.:.:|.....||.|.:|...:..|..|        ||.|....||
Mouse   473 --------QERRSRMDLPGSPSRQACSSQPAQMLSVDT--------GHADRQASGR 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	79/299 (26%)
		SPS1	47..432	CDD:223589	102/413 (25%)
		Pol_alpha_B_N	<399..>502	CDD:285602	20/116 (17%)
Ttbk1	NP_001156336.1	STKc_TTBK1	33..294	CDD:271032	78/296 (26%)
		PHA03307	324..>683	CDD:223039	49/244 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..397		4/33 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..448		10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..671		12/47 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	720..899
		PHA03307	963..>1305	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	985..1085
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1097..1308
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740