DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ball and Vrk3

DIOPT Version :9

Sequence 1:	NP_651508.1	Gene:	ball / 43228	FlyBaseID:	FBgn0027889	Length:	599	Species:	Drosophila melanogaster
Sequence 2:	NP_598706.1	Gene:	Vrk3 / 101568	MGIID:	2182465	Length:	453	Species:	Mus musculus

Alignment Length:	384	Identity:	95/384 - (24%)
Similarity:	169/384 - (44%)	Gaps:	68/384 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RVAKPKAAAPAKKVVSAKKAKSKLYKMPEKVKEGTVFTDLAKGQWRIGPSIGVGGFGEIYAA--- 64
            |...||.:..:.:.......::::....:.:..||..||.....|.:|........|.:|.|
Mouse   101 RPLTPKGSPLSNRQSPQTLKRTRVTTSLQALATGTELTDQNGKHWTLGALQIRDDQGILYEAEPT 165

  Fly    65 ---------------CKVGEKNYDAVVKCEPHGNGPLFVEMHFYLRNAKLEDIKQFMQKHGLKSL 114
                           .|:..|            :|.||.|.:|:.|.||...:.::.::..|..|
Mouse   166 SAVPSESRTQKWRFSLKLDSK------------DGRLFNEQNFFQRVAKPLQVNKWKKQFLLPLL 218

  Fly   115 GMPYILANGSVEVNGEKHRFIVMPRYGSDLTKFLEQNGKR-LPEGTVYRLAIQMLDVYQYMHSNG 178
            .:|..:..|   ::.:|:||:|.|..|..|...|:.|.|. :.|..|.::|.::||..:|:|.|.
Mouse   219 AIPTCIGFG---IHQDKYRFLVFPSLGRSLQSALDDNPKHVVSERCVLQVACRLLDALEYLHENE 280

  Fly   179 YVHADLKAANILLGLEKGGAAQAYLVDFGLASHFVTGD----FKPDPKKMHNGTIEYTSRDAHLG 239
            |||.:|.|.|:.:..|  ..:|..||.:|....:..|.    :|...:..|:|.:|:.|.|.|.|
Mouse   281 YVHGNLTAENVFVNPE--DLSQVTLVGYGFTYRYCPGGKHVAYKEGSRSPHDGDLEFISMDLHKG 343

  Fly   240 V-PTRRADLEILGYNLIEWLGAELPWVTQKLLAVPPKVQKAKEAFMDN----IG---------ES 290
            . |:||:||:.|||.:::||...|||.  ..|....|:.:.|:.::|:    :|         |:
Mouse   344 CGPSRRSDLQTLGYCMLKWLYGSLPWT--NCLPNTEKITRQKQKYLDSPERLVGLCGRWNKASET 406

  Fly   291 LKTLFPKGVPPPIGDFMKYVSKLTHNQEPDYDKCRSWFSSALKQLKIPNNGDLDFKMKP 349
            |:            :::|.|..|.:.::|.|...|:...:.|:.:::.....||.:|.|
Mouse   407 LR------------EYLKVVMALNYEEKPPYATLRNSLEALLQDMRVSPYDPLDLQMVP 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ball	NP_651508.1	STKc_VRK	36..328	CDD:270917	87/328 (27%)
		SPS1	47..432	CDD:223589	88/340 (26%)
		Pol_alpha_B_N	<399..>502	CDD:285602
Vrk3	NP_598706.1	zinc_ribbon_2	4..26	CDD:379084
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	30..123		3/21 (14%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:14645249	49..64
		PKc_like	134..436	CDD:389743	87/332 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1164
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11909
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.800