DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS12 and Phf19

DIOPT Version :9

Sequence 1:	NP_651507.1	Gene:	IntS12 / 43227	FlyBaseID:	FBgn0039459	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_082992.1	Gene:	Phf19 / 74016	MGIID:	1921266	Length:	578	Species:	Mus musculus

Alignment Length:	73	Identity:	21/73 - (28%)
Similarity:	29/73 - (39%)	Gaps:	18/73 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 IVNTGDTGDFGDLNCCVCGEMVFTATNRLIECSKCGAMYHQECHKP-------PITKEEAADDQE 174
            |.:.|..|:  :..|.||........|.::.|.|||..|||:||.|       |:.
Mouse    85 IQHAGVPGE--EPKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLL--------- 138

  Fly   175 QNWQCDTC 182
            .:|.|..|
Mouse   139 THWFCRRC 146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS12	NP_651507.1	PHD_Int12	130..182	CDD:276976	17/58 (29%)
Phf19	NP_082992.1	Tudor_2	41..76	CDD:375553
		Histone H3K36me3 binding. /evidence=ECO:0000250	72..78
		PHD_SF	96..148	CDD:389947	18/60 (30%)
		PHD2_PHF19	195..246	CDD:277056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..390
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	486..528
		Interaction with SUZ12. /evidence=ECO:0000250\|UniProtKB:Q5T6S3	529..578
		Mtf2_C	529..576	CDD:372898
		Important for PRC2 dimer stability. /evidence=ECO:0000250\|UniProtKB:Q5T6S3	529..542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900