DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS12 and INTS12

DIOPT Version :9

Sequence 1:	NP_651507.1	Gene:	IntS12 / 43227	FlyBaseID:	FBgn0039459	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001135943.1	Gene:	INTS12 / 57117	HGNCID:	25067	Length:	462	Species:	Homo sapiens

Alignment Length:	434	Identity:	109/434 - (25%)
Similarity:	167/434 - (38%)	Gaps:	119/434 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AAAAAQEVDPVLKKAIKLLHSSNPTSAAELRLLLDEAL------------KARFGPEKSLTNNMT 60
            ||....|:||:..||:..|||.:..||.:|:.||||:|            |....|:.|.|.|::
Human     2 AATVNLELDPIFLKALGFLHSKSKDSAEKLKALLDESLARGIDSSYRPSQKDVEPPKISSTKNIS 66

  Fly    61 ----PRMLED--EANFSGRAATP----------PQQPINAD--EIINLTNSP--DKEPSDSVDTI 105
                |::...  ..|.:|:..|.          |...:.:|  |.:::...|  :|..:.|....
Human    67 IKQEPKISSSLPSGNNNGKVLTTEKVKKEAEKRPADKMKSDITEGVDIPKKPRLEKPETQSSPIT 131

  Fly   106 ADSDDGLSAVGIVNTGDTG--DFG---DLNCCVCGEMVFTATNRLIECSKCGAMYHQECHKPPIT 165
            ..|...|....:.:..:|.  ||.   .|.|.||.:|:..:.|:|:||.:|..:||::||||.:|
Human   132 VQSSKDLPMADLSSFEETSADDFAMEMGLACVVCRQMMVASGNQLVECQECHNLYHRDCHKPQVT 196

  Fly   166 KEEAADDQEQNWQCDTCCNKPTSSGRTTS--------SAAAVTP-----------------TVFI 205
            .:| |:|....|.|..|..:.....:.|.        :..:|||                 |.|:
Human   197 DKE-ANDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPAVVSVTPAVKDPLVKKPETKLKQETTFL 260

  Fly   206 ADEPMPLTSKAKSSVASSRSSNSSNSSSPFYRPEPSSSTNASSSSSSKHGHKSSSSSSSKSHKEE 270
            |   ...|....|:|.|..||::|.|||........::..|.:||:.....|.||::.:.:.|..
Human   261 A---FKRTEVKTSTVISGNSSSASVSSSVTSGLTGWAAFAAKTSSAGPSTAKLSSTTQNNTGKPA 322

  Fly   271 RSSKS--------TAASSLSAIGGMEKHNSS---------------------------------- 293
            .||.:        .|.||...||.....|:|
Human   323 TSSANQKPVGLTGLATSSKGGIGSKIGSNNSTTPTVPLKPPPPLTLGKTGLSRSVSCDNVSKVGL 387

  Fly   294 --------GTSSRRSG---SSTKSSSKSSSSKHHESGSSSKRRS 326
                    |:||:.||   |.|...|.|::||.....|||...|
Human   388 PSPSSLVPGSSSQLSGNGNSGTSGPSGSTTSKTTSESSSSPSAS 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS12	NP_651507.1	PHD_Int12	130..182	CDD:276976	21/51 (41%)
INTS12	NP_001135943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..132		15/89 (17%)
		PHD_Int12	161..212	CDD:276976	21/51 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	301..462		30/131 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140738
Domainoid	1	1.000	58	1.000	Domainoid score	I10822
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	87	1.000	Inparanoid score	I5152
Isobase	1	0.950	-	0	Normalized mean entropy	S6919
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1631937at2759
OrthoFinder	1	1.000	-	-		FOG0006596
OrthoInspector	1	1.000	-	-		oto90102
orthoMCL	1	0.900	-	-		OOG6_107743
Panther	1	1.100	-	-	LDO	PTHR13415
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3479
SonicParanoid	1	1.000	-	-		X5595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.740