DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IntS12 and PHF1

DIOPT Version :9

Sequence 1:	NP_651507.1	Gene:	IntS12 / 43227	FlyBaseID:	FBgn0039459	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_077084.2	Gene:	PHF1 / 5252	HGNCID:	8919	Length:	567	Species:	Homo sapiens

Alignment Length:	149	Identity:	38/149 - (25%)
Similarity:	52/149 - (34%)	Gaps:	41/149 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 PRMLEDEANFSGRAATPPQQPINADEIINLTNSPDKEPSDSVDTIADSDDGLSAVGIVNTGDTG- 124
            ||:....|:.....|:|..           |:.|.....:..|.:|...|||..:|.:...|:.
Human     5 PRLSRSGASSLWDPASPAP-----------TSGPRPRLWEGQDVLARWTDGLLYLGTIKKVDSAR 58

  Fly   125 -----DFGD--------------------LNCCVCGEMVFTATNRLIECSKCGAMYHQECHKPPI 164
                 .|.|                    |.||||........|||:.|.||...|||:||.|
Human    59 EVCLVQFEDDSQFLVLWKDISPAALPGEELLCCVCRSETVVPGNRLVSCEKCRHAYHQDCHVP-- 121

  Fly   165 TKEEAADDQE-QNWQCDTC 182
             :..|..:.| .:|.|..|
Human   122 -RAPAPGEGEGTSWVCRQC 139

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS12	NP_651507.1	PHD_Int12	130..182	CDD:276976	20/52 (38%)
PHF1	NP_077084.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31		7/36 (19%)
		Tudor_2	34..69	CDD:375553	9/34 (26%)
		PHD1_PHF1	89..139	CDD:276975	20/52 (38%)
		PHD2_PHF1	188..239	CDD:277057
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	333..441
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..537
		Mtf2_C	<539..565	CDD:372898
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900