DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS12 and ints12

DIOPT Version :9

Sequence 1:	NP_651507.1	Gene:	IntS12 / 43227	FlyBaseID:	FBgn0039459	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	NP_001002161.2	Gene:	ints12 / 415251	ZFINID:	ZDB-GENE-040625-178	Length:	479	Species:	Danio rerio

Alignment Length:	410	Identity:	102/410 - (24%)
Similarity:	170/410 - (41%)	Gaps:	104/410 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AAAAAQEVDPVLKKAIKLLHSSNPTSAAELRLLLDEALKARFGPEKSLTNNM---------TPRM 63
            |...:.|:||:..|.:..|||.:..||.:|:.||||:| || |.:....|::         .|:|
Zfish     2 AGTVSLELDPIFLKGLGYLHSKSKDSAEKLKALLDESL-AR-GSDSIYRNSIKEAEVSKVSLPKM 64

  Fly    64 LEDEANFSGRAATPPQQPINADEIINLTNSPDKE------------PSDSVD----TIADSDDGL 112
            .:.::..|..::.......:.....:::....||            |.:.|:    ...:..|..
Zfish    65 TKQDSKSSSSSSVSSSITTSNSSKSSISEKSKKESEKRTLEKIRVDPGEGVEPPKKPRLEKQDSH 129

  Fly   113 SAVGIVNTGD--TGDFGDLN--------------CCVCGEMVFTATNRLIECSKCGAMYHQECHK 161
            |:.....|.|  ..||.|::              |.||.:|..|:.|:|:||.:|..:|||||||
Zfish   130 SSPIAFQTKDIPIPDFTDIDETNADDFAMEMGLACVVCRQMTVTSGNQLVECQECHNLYHQECHK 194

  Fly   162 PPITKEEAADDQEQNWQCDTCCNKPTSSGRTTSS-----AAAVTPTVFIADEPM---------PL 212
            |.:|.:: .:|....|.|..|..:.....:.|..     |.|:..||.:..:|:         |.
Zfish   195 PQVTDKD-VNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPALATTVPLLKDPLVKKAELKPKPE 258

  Fly   213 T---------SKAKSSVASSRSSNSSNSSSPFYRPEPSSSTNASSSSSSKHGHKSSSSSSSKSHK 268
            |         ::.|::.||..||:||:|||..  |...:...|.:.::|..|..|:..|:|:|..
Zfish   259 TTGSFQAFKRTEVKATAASGNSSSSSSSSSSL--PPGLTGWAAFTKATSNVGPSSTKLSTSQSGN 321

  Fly   269 EERS-----SKSTAASSLSAI---------GGMEKHNSSGTSSRRSGSST--------------- 304
            .:.|     ||....|:|:.:         ||    :|:|:.:..:||.|
Zfish   322 SKTSPAASGSKPVGLSALANVKPALATKPSGG----SSAGSGNGNNGSGTVPLKAPPPLTLGKQV 382

  Fly   305 --KSSSKSSSSKHHESGSSS 322
              :|:|..|..|...:||.|
Zfish   383 LSRSASGDSLGKMTVTGSLS 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS12	NP_651507.1	PHD_Int12	130..182	CDD:276976	22/65 (34%)
ints12	NP_001002161.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	57..140		10/82 (12%)
		PHD_Int12	163..214	CDD:276976	22/51 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..241		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	274..293		10/20 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..479		25/102 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573451
Domainoid	1	1.000	59	1.000	Domainoid score	I10717
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I5069
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1631937at2759
OrthoFinder	1	1.000	-	-		FOG0006596
OrthoInspector	1	1.000	-	-		oto38640
orthoMCL	1	0.900	-	-		OOG6_107743
Panther	1	1.100	-	-	LDO	PTHR13415
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3479
SonicParanoid	1	1.000	-	-		X5595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790