DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IntS12 and Ints12

DIOPT Version :9

Sequence 1:	NP_651507.1	Gene:	IntS12 / 43227	FlyBaseID:	FBgn0039459	Length:	328	Species:	Drosophila melanogaster
Sequence 2:	XP_006233382.1	Gene:	Ints12 / 295448	RGDID:	1359136	Length:	467	Species:	Rattus norvegicus

Alignment Length:	376	Identity:	101/376 - (26%)
Similarity:	153/376 - (40%)	Gaps:	78/376 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 IAAAAAAAQEVDPVLKKAIKLLHSSNPTSAAELRLLLDEAL----KARFGP------------EK 53
            :|.||....|:||:..||:..|||.:..||.:|:.||||:|    .|.:.|            .|
  Rat     5 LAMAATVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDASYRPAQKDVEPPKISSTK 69

  Fly    54 SLTNNMTPR------------------MLEDEANFSGRAATPPQQPINADEIINLTNSP---DKE 97
            ||:....|:                  .|:.||.     ..|..:..:|.|.:::...|   ..|
  Rat    70 SLSIKQEPKTSSSLPSGSSNGKVLAAEKLKKEAE-----KRPADKMKDATEGVDVPKKPRLEKPE 129

  Fly    98 PSDSVDTIADSDDGLSAVGIVNTGDTG--DFG---DLNCCVCGEMVFTATNRLIECSKCGAMYHQ 157
            ...|..|:..|.| |:...:.:..:|.  ||.   .|.|.||.:|...:.|:|:||.:|..:|||
  Rat   130 TRSSPITVQTSKD-LAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQ 193

  Fly   158 ECHKPPITKEEAADDQEQNWQCDTCCNKPTSSGRTTS--------SAAAVTPTVFIADEPMPLTS 214
            :||||.:|.:| .:|....|.|..|..:.....:.|.        :..:|.|||     ..||..
  Rat   194 DCHKPQVTDKE-VNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPTV-----KDPLVK 252

  Fly   215 KAKSSVASSRSSNSSNSSSPFYRPEPSSSTNASSSSSSKHGHKSSSSSSSKSHKEERSSKSTAAS 279
            |.::.:      ....:...|.|.|...||..|.:|||  .:.|||.:|..:.....::|:::|.
  Rat   253 KPETKL------KQETTFLAFKRTEVKPSTVISGNSSS--NNVSSSVTSGLTGWAAFAAKTSSAG 309

  Fly   280 SLSAIGGMEKHNSSGTSSRRSGSS--------TKSSSKSSSSKHHESGSSS 322
            ..:|.......||||..:..|.|.        ..||.....||...|.|:|
  Rat   310 PSTAKLNSTAQNSSGKPAASSASQKPVGLTGLATSSKGGIGSKIGSSNSTS 360

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IntS12	NP_651507.1	PHD_Int12	130..182	CDD:276976	21/51 (41%)
Ints12	XP_006233382.1	PHD_Int12	166..217	CDD:276976	21/51 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334424
Domainoid	1	1.000	57	1.000	Domainoid score	I10660
eggNOG	1	0.900	-	-		E1_KOG4323
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I5038
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1631937at2759
OrthoFinder	1	1.000	-	-		FOG0006596
OrthoInspector	1	1.000	-	-		oto97219
orthoMCL	1	0.900	-	-		OOG6_107743
Panther	1	1.100	-	-	LDO	PTHR13415
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5595
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760