DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lerp and MRL1

DIOPT Version :9

Sequence 1:	NP_001262996.1	Gene:	Lerp / 43223	FlyBaseID:	FBgn0051072	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_015404.1	Gene:	MRL1 / 856194	SGDID:	S000006283	Length:	381	Species:	Saccharomyces cerevisiae

Alignment Length:	274	Identity:	57/274 - (20%)
Similarity:	101/274 - (36%)	Gaps:	76/274 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 ANEVCSFYISYRTPLACLSIPEGLQSNS-----CRVGDTKSNGTFDLMPLSD------------- 222
            |||..:.:...||    |:.|:..:|.:     |.|.:..:....||..||.
Yeast    34 ANEHRASHKQKRT----LANPDKPKSENDEDLFCAVTNPVTGSYIDLSQLSSTPNKLREGQKQIS 94

  Fly   223 -SNYHTSNR---------QGAFFVINVC-KPVLYGENSMCPAGSSVCLFDSKATNPKERFINFGN 276
             :|.|.|::         ....|.:.:| .||...|:......:.....|....|   ..::.|:
Yeast    95 GNNKHESSKTKWSVRGWGYDTNFTLGICSSPVGEAESQQLSNLTGAFYVDQLNEN---NLVSIGD 156

  Fly   277 VQTHPVVEKG----QLLLRHESPTPCAKNSSANYTSVIYFSCDKFIRN-AHPEFAGLGADSCTYQ 336
            ..|.|.:..|    :|.|::|:.:.| .|......:::.|.|||.|:: |...:.| ...:|:|.
Yeast   157 FSTRPALVGGSTAKKLTLKYENGSMC-PNGKDKKATLLNFVCDKEIQSKAQISYIG-NLHNCSYF 219

  Fly   337 FNFATPLAC------NDLKPCTAF--------------------------TSTNELLDLS-SLSS 368
            |...:..||      |::.....|                          .:.:||.|:| ||:.
Yeast   220 FEVRSIHACPTSNKKNEVNVLGIFIGIFAIFFLVEFAGRRWIYAKLNRHLKNDDELHDISPSLNE 284

  Fly   369 KPARTLLKDGKNYT 382
            :|...|::||..::
Yeast   285 QPHWDLIEDGSRWS 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lerp	NP_001262996.1	CIMR	<49..143	CDD:279250
		CIMR	157..298	CDD:279250	31/154 (20%)
		CIMR	307..435	CDD:279250	24/110 (22%)
		CIMR	445..>574	CDD:279250
		CIMR	623..>666	CDD:279250
MRL1	NP_015404.1	CIMR	188..>229	CDD:395706	11/41 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006150
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1957
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930