DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lerp and igf2r

DIOPT Version :9

Sequence 1:	NP_001262996.1	Gene:	Lerp / 43223	FlyBaseID:	FBgn0051072	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_001034716.1	Gene:	igf2r / 557061	ZFINID:	ZDB-GENE-041014-300	Length:	2459	Species:	Danio rerio

Alignment Length:	793	Identity:	202/793 - (25%)
Similarity:	339/793 - (42%)	Gaps:	124/793 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CKLKEPIYGSTFDFSGLHSDLAHVVKSMNIGGDQFEFNICGNLSRT-C--NGESNVAACLKRQGK 116
            ||:.:|..|..::.:.| :...:.|||...   ::.|.:||.::.: |  :...:|::|.....|
Zfish  1210 CKVTDPKSGYEYNLTPL-AGQDYEVKSSTY---EYHFAVCGPITTSVCLHDASQSVSSCQVENQK 1270

  Fly   117 EYILG-RQHELFYNNGNMFLKYKSGAKC----DNGTADKPNYQLHVMFSCDYTLD-AQPMHVTPY 175
            ..|.| ....|.:::|.:.:.|.:|..|    :..||        ::||||::.: .:|..:...
Zfish  1271 HRIAGIANQNLTFDDGIIMINYTNGETCHKIYERSTA--------ILFSCDHSRNPGKPDFIKET 1327

  Fly   176 ANEVCSFYISYRTPLACLSIPEGLQSNSCRVGDTKSNGTFDL--MPLSDSNY----HTSNRQGAF 234
            |:  |::...:.|.|||.|    .::.:|...| .|..::||  :.|..||:    .:||::..:
Zfish  1328 AD--CTYLFEWHTALACPS----FKTTTCSYND-GSGHSYDLSSLALHKSNWIVVPESSNQKQRY 1385

  Fly   235 FVINVCKPVLYGENSM--CPAGSSVCLFDSKATNPKERFINFGNVQTHPVVEKGQLLLRHESPTP 297
            : |||||. |..:..:  ||:.::.||.|.      :.::|.|..::.|..:|..|:|::.:...
Zfish  1386 Y-INVCKS-LVPQTGLWSCPSSAAACLKDG------DEYVNLGEAESGPQWDKNVLVLKYTNGKA 1442

  Fly   298 CAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLAC-------NDLKPCTAFT 355
            | .:...|.|::|.|.|:....::.|... ...::|.|.|.:.|..||       .|.|  ....
Zfish  1443 C-PDGKRNRTTIIRFKCNPDKVDSEPTLI-TALENCVYSFVWFTAAACPLNSTEHGDCK--VTNP 1503

  Fly   356 STNELLDLSSLSSKPARTLL---KDGKNYTIAVCAH-AGAPCQENGGACYEQNSTTISLGNSNSQ 416
            :|..|.||::||.....|:.   ...|.:.:.||.. ..|.|....|.|.:.|...||.|.::.:
Zfish  1504 ATGHLFDLNALSRAGGYTVYDPESHRKMFRLNVCGEIINAGCATGTGVCIKDNQMAISAGKASRK 1568

  Fly   417 LRF-NQTGSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSLKII--EDSN 478
            |.: ||.  :.|.||||..||  |..|:..:...|||         .|..||:|...::  :|:.
Zfish  1569 LVYKNQV--VELSYEDGDACS--TNSRKHKSIFSFVC---------KSEGGGTDGPVLVYSDDTT 1620

  Fly   479 CQLLIQYQTPLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVELPASMEHL 543
            |.....:.|||.|.:.::|...            :|...|||:|||..|..|.|   :...::.
Zfish  1621 CTHFFTWHTPLVCEQQVKCSVW------------NGTNQIDLSPLIHLTGYYTA---IDEDVDR- 1669

  Fly   544 VPKTTKFFLNVCRPLVPKYQLGCAGGSAACMAKVTAAGAP-EEERSMGFPLVSLTQRNRTFAELA 607
             .|:..|::|:|:||.|..::.|..|:|.||..|.  |.| :..|....|..:...:.   .|:.
Zfish  1670 -DKSPDFYINICQPLNPIPRVNCPPGAAVCMDPVD--GEPIDIGRITSPPRYNSESKE---VEIT 1728

  Fly   608 YLKGDPCPTDNTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPHECTFSADTCD 672
            :.....|.::.||..|:.|:|.|...|..|.|.:.....|.|.|||.|.|.||.   ...|..|:
Zfish  1729 FSSTTVCASNRTSNYSSKIIFTCQKGAELGSPRMIRAHSCMYVFEWATPVVCPE---IIEAQGCN 1790

  Fly   673 LVHDELGRRFNFKSAPFTKDGKIEIDYNATKMSVNICGAHRKAMTDYSQALVNIFFTHESPNCGR 737
            |...:|  |:.|..:..|  |.:::...:...|:|:||.  .|.|....:.|.:..:....:.|.
Zfish  1791 LTVSQL--RYTFDLSALT--GPVQVPVTSGSFSINVCGT--VANTTCKDSAVCLISSGSRASYGN 1849

  Fly   738 EGTMNVQIRLICSDQTESSSTI---SSDQQCNLLYVQRTPSICEFLSLGATQQNFESNGSTSSST 799
            ...||:..:      .|..|.|   |....|.  .|.....:|.|..:      ..||..|..:|
Zfish  1850 AKLMNLDYK------REEQSVIMQYSGGDPCP--QVTDKHEVCAFPFM------ILSNNYTECTT 1900

  Fly   800 SSSSTSTTTSTTT 812
            .|.:.......||
Zfish  1901 ESRTDGRKWCATT 1913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lerp	NP_001262996.1	CIMR	<49..143	CDD:279250	21/91 (23%)
		CIMR	157..298	CDD:279250	39/149 (26%)
		CIMR	307..435	CDD:279250	39/139 (28%)
		CIMR	445..>574	CDD:279250	34/130 (26%)
		CIMR	623..>666	CDD:279250	16/42 (38%)
igf2r	NP_001034716.1	ATG27	52..>177	CDD:286529
		CIMR	117..231	CDD:279250
		CIMR	413..562	CDD:279250
		CIMR	570..707	CDD:279250
		CIMR	712..863	CDD:279250
		CIMR	1012..1160	CDD:279250
		CIMR	1166..1298	CDD:279250	21/91 (23%)
		CIMR	1302..1444	CDD:279250	42/165 (25%)
		CIMR	1448..1586	CDD:279250	40/142 (28%)
		CIMR	1591..1735	CDD:279250	43/174 (25%)
		CIMR	1744..1875	CDD:279250	38/145 (26%)
		fn2	1884..1925	CDD:278469	9/36 (25%)
		CIMR	1932..2068	CDD:279250
		CIMR	2225..>2262	CDD:279250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578432
Domainoid	1	1.000	57	1.000	Domainoid score	I10911
eggNOG	1	0.900	-	-		E1_KOG4504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006150
OrthoInspector	1	1.000	-	-		oto41001
orthoMCL	1	0.900	-	-		OOG6_105199
Panther	1	1.100	-	-	LDO	PTHR15071
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1957
SonicParanoid	1	1.000	-	-		X5083
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730