DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lerp and m6pr

DIOPT Version :9

Sequence 1:	NP_001262996.1	Gene:	Lerp / 43223	FlyBaseID:	FBgn0051072	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_998370.1	Gene:	m6pr / 406486	ZFINID:	ZDB-GENE-040426-2285	Length:	265	Species:	Danio rerio

Alignment Length:	197	Identity:	39/197 - (19%)
Similarity:	69/197 - (35%)	Gaps:	45/197 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 VISLLLLLFCSGESVAADAANQLKFSTTECK-------------LKEPIYGSTFDFSGLHSDLAH 77
            :|:.|.:||         |..|.:|:|:.||             |.||:....|...|...:...
Zfish     7 IITPLFVLF---------AGVQARFNTSNCKLVSDSESQRKALRLLEPLTNQNFTTEGQEKEKYS 62

  Fly    78 VVKSMNIGGDQFEFNICGNLSRTCNGESNVAACLKRQGKEYI-LGRQHELFYNNGN--MFLKYKS 139
            .:           |.:||:    ..|..|.....:.:|.:.| :|...:.....|:  :.|.|:.
Zfish    63 YI-----------FQVCGD----AGGVKNAGLIQQEKGGKTIRIGDYSKTVATAGSDWVLLIYEG 112

  Fly   140 GAKCDNGTADKPNYQLHVMFSCDYTLDAQPMHVTPYANEV---CSFYISYRTPLACLSIPEGLQS 201
            |.|.|:..:.:....: :|.||. :.......|....|:.   |.:.....|...|.::...|.:
Zfish   113 GEKYDSHCSSEERKAM-IMISCS-SSSKSAFSVVMEENQKQKNCYYLFELDTTAVCPAVSSKLSA 175

  Fly   202 NS 203
            .|
Zfish   176 GS 177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lerp	NP_001262996.1	CIMR	<49..143	CDD:279250	21/109 (19%)
		CIMR	157..298	CDD:279250	10/50 (20%)
		CIMR	307..435	CDD:279250
		CIMR	445..>574	CDD:279250
		CIMR	623..>666	CDD:279250
m6pr	NP_998370.1	Man-6-P_recep	11..265	CDD:280342	38/193 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1957
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030