Protein Alignment Lerp and Igf2r

DIOPT Version :10

• Sequence 1: NP_001262996.1
• Gene: Lerp / 43223
• FlyBaseID: FBgn0051072
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_036888.2
• Gene: Igf2r / 25151
• RGDID: 2871
• Length: 2481
• Species: Rattus norvegicus
• Alignment Length: 750
• Identity: 203/750 - (27%)
• Similarity: 309/750 - (41%)
• Gaps: 114/750 - (15%)

  Fly    55 CKLKEPIYGSTFDFSGLHSDLAHVVKSMNIGGDQFEFNICGNLS-RTC---NGESNVAACLKR-- 113
            |::|:|.:|:.:|.    ..||.....::.|...:.|.:||.|| ..|   :|...|::|.::
  Rat  1218 CQVKDPRHGNLYDL----KPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKG 1278

  Fly   114 -QGKEYILG-RQHELFYNNGNMFLKYKSGAKCDNGTADKPNYQ--LHVMFSCDYTLDAQPMHVTP 174
             ||.:.:.| ...:|.:.||.:.:.|..|..|..      .||  ..:.|.||.|.. :|:.:..
  Rat  1279 PQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHK------VYQRSTTIYFYCDRTTQ-KPVFLKE 1336

  Fly   175 YANEVCSFYISYRTPLAC--LSIPEGLQSNSCRVGDTKSNGTFDLMPLS--DSNYHTSNRQGA-- 233
            ..:  ||:...:||..||  .::.|      |.:.|...| :.||..||  ..|:....|.||
  Rat  1337 TLD--CSYLFEWRTQYACPPFNVTE------CSIQDEAGN-SIDLSSLSRYSDNWEAVTRTGATE 1392

  Fly   234 FFVINVCKPVL-YGENSMCPAGSSVCLFDSKATNPKERFINFGNVQTHPVVEKGQLLLRHESPTP 297
            .::|||||.:. ......||..::|||.|  .:.|    :|.|.|:..|....|..:|::.....
  Rat  1393 HYLINVCKSLSPQAGTDPCPPEAAVCLLD--GSKP----VNLGRVRDGPQWTAGVTVLKYVDGDL 1451

  Fly   298 CAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLAC----NDLKPCTAFT-ST 357
            | .:.....:::|.|:|.....|:.|.|.....| |.|.|::.||.||    |....|.... ||
  Rat  1452 C-PDKIRKRSTIIRFTCSDSQVNSRPLFISAVQD-CEYTFSWPTPAACPVKSNIHDDCQVTNPST 1514

  Fly   358 NELLDLSSLSSKPARTLLKDGKNYTIAVCAHAGAPCQENGGACYEQNSTTISLGNSNSQLRFNQT 422
            ..|.||||||.|...|.....|.............|....|||:.|  |.||:|.::.:|.:...
  Rat  1515 GHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQ--TRISVGQASKRLSYKDQ 1577

  Fly   423 GSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSLKIIEDSNCQLLIQYQT 487
             .|.|:||:|:.|.:.:|: |:.:.|.|||...|...|       ...|..::..:|.|...:.|
  Rat  1578 -VLQLVYENGSPCPSKSGL-RYKSVISFVCRPEAGPTN-------RPMLISLDKQSCTLFFSWHT 1633

  Fly   488 PLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVELPASMEHLVPKTTKFFL 552
            ||||.:...|..            .:|..:|||:|||..|..|||..|   |.:.....|..|::
  Rat  1634 PLACEQATECTV------------RNGSSIIDLSPLIHRTGGYEAYDE---SEDDTSDTTPDFYI 1683

  Fly   553 NVCRPLVPKYQLGCAGGSAACMAKVTAAGAPEEERSMGFPLVSLTQRNRTFAELAYLKGDPCPTD 617
            |:|:||.|.:.:.|..|::.|  ||...|.|.:...:..|.:.....|..:  |.:....||..|
  Rat  1684 NICQPLNPMHGVPCPAGASVC--KVPVDGPPIDIGRVTGPPIFNPVANEVY--LNFESSTPCLAD 1744

  Fly   618 NTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPHECTFSADTCDLVHDELGRRF 682
            .....::.|.|:|......|.|.|....||.:.|||||.:.||....|   ..|.:..::|...|
  Rat  1745 KYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKT---QGCAVTDEQLLYSF 1806

  Fly   683 NFKSAPFTKDGKIEIDYNATKMSVNICGAHRKAMTDYSQALVNIFFTHESPNCGREGTMNVQIRL 747
            |..|.. |...|:..|  |...|:.:|    ....|..|                ||..:..:.|
  Rat  1807 NLTSLS-TSTFKVTRD--AHTYSIGVC----TTAADLDQ----------------EGCKDGGVCL 1848

  Fly   748 ICSDQTESSSTISS--------DQQCNLLYVQRTP 774
            :...:..|...::|        |:...|.||...|
  Rat  1849 LSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDP 1883

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lerp	NP_001262996.1	CIMR	<49..143	CDD:425923	25/95 (26%)
		CIMR	157..298	CDD:425923	41/147 (28%)
		CIMR	307..435	CDD:425923	43/132 (33%)
		CIMR	445..>574	CDD:425923	37/128 (29%)
		CIMR	623..>666	CDD:425923	15/42 (36%)
Igf2r	NP_036888.2	CIMR	119..258	CDD:425923
		ATG27	321..>465	CDD:476860
		CIMR	416..566	CDD:425923
		CIMR	568..708	CDD:425923
		CIMR	715..867	CDD:425923
		CIMR	1022..1169	CDD:425923
		ATG27	1208..>1354	CDD:476860	39/148 (26%)
		CIMR	1313..1453	CDD:425923	44/156 (28%)
		CIMR	1457..1590	CDD:425923	43/136 (32%)
		CIMR	1599..1722	CDD:425923	42/146 (29%)
		CIMR	1750..1885	CDD:425923	38/159 (24%)
		FN2	1888..1933	CDD:128373
		CIMR	1940..2074	CDD:425923
		CIMR	2080..>2141	CDD:425923
		CIMR	2232..>2271	CDD:425923