DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lerp and Igf2r

DIOPT Version :9

Sequence 1:	NP_001262996.1	Gene:	Lerp / 43223	FlyBaseID:	FBgn0051072	Length:	918	Species:	Drosophila melanogaster
Sequence 2:	NP_036888.2	Gene:	Igf2r / 25151	RGDID:	2871	Length:	2481	Species:	Rattus norvegicus

Alignment Length:	750	Identity:	203/750 - (27%)
Similarity:	309/750 - (41%)	Gaps:	114/750 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CKLKEPIYGSTFDFSGLHSDLAHVVKSMNIGGDQFEFNICGNLS-RTC---NGESNVAACLKR-- 113
            |::|:|.:|:.:|.    ..||.....::.|...:.|.:||.|| ..|   :|...|::|.::
  Rat  1218 CQVKDPRHGNLYDL----KPLALNDTIISAGEYTYYFRVCGKLSLDVCSAHDGSKAVSSCQEKKG 1278

  Fly   114 -QGKEYILG-RQHELFYNNGNMFLKYKSGAKCDNGTADKPNYQ--LHVMFSCDYTLDAQPMHVTP 174
             ||.:.:.| ...:|.:.||.:.:.|..|..|..      .||  ..:.|.||.|.. :|:.:..
  Rat  1279 PQGFQKVAGLLNQKLTFENGLLKMNYSGGDTCHK------VYQRSTTIYFYCDRTTQ-KPVFLKE 1336

  Fly   175 YANEVCSFYISYRTPLAC--LSIPEGLQSNSCRVGDTKSNGTFDLMPLS--DSNYHTSNRQGA-- 233
            ..:  ||:...:||..||  .::.|      |.:.|...| :.||..||  ..|:....|.||
  Rat  1337 TLD--CSYLFEWRTQYACPPFNVTE------CSIQDEAGN-SIDLSSLSRYSDNWEAVTRTGATE 1392

  Fly   234 FFVINVCKPVL-YGENSMCPAGSSVCLFDSKATNPKERFINFGNVQTHPVVEKGQLLLRHESPTP 297
            .::|||||.:. ......||..::|||.|  .:.|    :|.|.|:..|....|..:|::.....
  Rat  1393 HYLINVCKSLSPQAGTDPCPPEAAVCLLD--GSKP----VNLGRVRDGPQWTAGVTVLKYVDGDL 1451

  Fly   298 CAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLAC----NDLKPCTAFT-ST 357
            | .:.....:::|.|:|.....|:.|.|.....| |.|.|::.||.||    |....|.... ||
  Rat  1452 C-PDKIRKRSTIIRFTCSDSQVNSRPLFISAVQD-CEYTFSWPTPAACPVKSNIHDDCQVTNPST 1514

  Fly   358 NELLDLSSLSSKPARTLLKDGKNYTIAVCAHAGAPCQENGGACYEQNSTTISLGNSNSQLRFNQT 422
            ..|.||||||.|...|.....|.............|....|||:.|  |.||:|.::.:|.:...
  Rat  1515 GHLFDLSSLSGKAGITASYSEKGMVFMSICEENVNCSPGVGACFGQ--TRISVGQASKRLSYKDQ 1577

  Fly   423 GSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSLKIIEDSNCQLLIQYQT 487
             .|.|:||:|:.|.:.:|: |:.:.|.|||...|...|       ...|..::..:|.|...:.|
  Rat  1578 -VLQLVYENGSPCPSKSGL-RYKSVISFVCRPEAGPTN-------RPMLISLDKQSCTLFFSWHT 1633

  Fly   488 PLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVELPASMEHLVPKTTKFFL 552
            ||||.:...|..            .:|..:|||:|||..|..|||..|   |.:.....|..|::
  Rat  1634 PLACEQATECTV------------RNGSSIIDLSPLIHRTGGYEAYDE---SEDDTSDTTPDFYI 1683

  Fly   553 NVCRPLVPKYQLGCAGGSAACMAKVTAAGAPEEERSMGFPLVSLTQRNRTFAELAYLKGDPCPTD 617
            |:|:||.|.:.:.|..|::.|  ||...|.|.:...:..|.:.....|..:  |.:....||..|
  Rat  1684 NICQPLNPMHGVPCPAGASVC--KVPVDGPPIDIGRVTGPPIFNPVANEVY--LNFESSTPCLAD 1744

  Fly   618 NTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPHECTFSADTCDLVHDELGRRF 682
            .....::.|.|:|......|.|.|....||.:.|||||.:.||....|   ..|.:..::|...|
  Rat  1745 KYMNYTSLIAFHCRRGISMGTPKLIRNNDCDFVFEWETPIVCPDEVKT---QGCAVTDEQLLYSF 1806

  Fly   683 NFKSAPFTKDGKIEIDYNATKMSVNICGAHRKAMTDYSQALVNIFFTHESPNCGREGTMNVQIRL 747
            |..|.. |...|:..|  |...|:.:|    ....|..|                ||..:..:.|
  Rat  1807 NLTSLS-TSTFKVTRD--AHTYSIGVC----TTAADLDQ----------------EGCKDGGVCL 1848

  Fly   748 ICSDQTESSSTISS--------DQQCNLLYVQRTP 774
            :...:..|...::|        |:...|.||...|
  Rat  1849 LSGSKGASFGRLASMQLDYRHQDEAVILSYVNGDP 1883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lerp	NP_001262996.1	CIMR	<49..143	CDD:279250	25/95 (26%)
		CIMR	157..298	CDD:279250	41/147 (28%)
		CIMR	307..435	CDD:279250	43/132 (33%)
		CIMR	445..>574	CDD:279250	37/128 (29%)
		CIMR	623..>666	CDD:279250	15/42 (36%)
Igf2r	NP_036888.2	CIMR	119..258	CDD:279250
		CIMR	416..566	CDD:279250
		CIMR	568..708	CDD:279250
		CIMR	715..867	CDD:279250
		CIMR	1022..1169	CDD:279250
		Man-6-P_recep	1202..>1354	CDD:280342	39/148 (26%)
		CIMR	1313..1453	CDD:279250	44/156 (28%)
		CIMR	1457..1590	CDD:279250	43/136 (32%)
		CIMR	1599..1722	CDD:279250	42/146 (29%)
		CIMR	1750..1885	CDD:279250	38/159 (24%)
		FN2	1888..1933	CDD:128373
		CIMR	1940..2074	CDD:279250
		CIMR	2080..>2141	CDD:279250
		CIMR	2232..>2271	CDD:279250
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338822
Domainoid	1	1.000	63	1.000	Domainoid score	I10045
eggNOG	1	0.900	-	-		E1_KOG4504
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006150
OrthoInspector	1	1.000	-	-		oto97031
orthoMCL	1	0.900	-	-		OOG6_105199
Panther	1	1.100	-	-	LDO	PTHR15071
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5083
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.700