DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lerp and Igf2r

DIOPT Version :9

Sequence 1:NP_001262996.1 Gene:Lerp / 43223 FlyBaseID:FBgn0051072 Length:918 Species:Drosophila melanogaster
Sequence 2:NP_034645.2 Gene:Igf2r / 16004 MGIID:96435 Length:2483 Species:Mus musculus


Alignment Length:752 Identity:198/752 - (26%)
Similarity:312/752 - (41%) Gaps:118/752 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 CKLKEPIYGSTFDFS--GLHSDLAHVVKSMNIGGDQFEFNICGNLSR-TC---NGESNVAACLKR 113
            |::|:|.:|:.:|..  ||:..:      :::|...:...:||.||. .|   :|...|::|.::
Mouse  1220 CQVKDPRHGNLYDLKPLGLNDTI------VSVGEYTYYLRVCGKLSSDVCSAHDGSKAVSSCQEK 1278

  Fly   114 ---QGKEYILG-RQHELFYNNGNMFLKYKSGAKCDNGTADKPNYQ--LHVMFSCDYTLDAQPMHV 172
               ||.:.:.| ...:|.:.||.:.:.|..|..|..      .||  ..:.|.||.|.. :|:.:
Mouse  1279 KGPQGFQKVAGLLSQKLTFENGLLKMNYTGGDTCHK------VYQRSTTIYFYCDRTTQ-KPVFL 1336

  Fly   173 TPYANEVCSFYISYRTPLAC--LSIPEGLQSNSCRVGDTKSNGTFDLMPLS--DSNYHTSNRQGA 233
            ...::  ||:...:||..||  .::.|      |.|.|...| :.||..||  ..|:....|.||
Mouse  1337 KETSD--CSYMFEWRTQYACPPFNVTE------CSVQDAAGN-SIDLSSLSRYSDNWEAVTRTGA 1392

  Fly   234 --FFVINVCKPVL-YGENSMCPAGSSVCLFDSKATNPKERFINFGNVQTHPVVEKGQLLLRHESP 295
              .::|||||.:. :.....||..::|||.:  .:.|    :|.|.|:..|....|..:|::...
Mouse  1393 TEHYLINVCKSLSPHAGTEPCPPEAAVCLLN--GSKP----VNLGKVRDGPQWTDGVTVLQYVDG 1451

  Fly   296 TPCAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLAC----NDLKPCTAFT- 355
            ..| .:.....:::|.|:|.....|:.|.|.....| |.|.|::.||.||    |....|.... 
Mouse  1452 DLC-PDKIRRRSTIIRFTCSDNQVNSRPLFISAVQD-CEYTFSWPTPSACPVKSNTHDDCQVTNP 1514

  Fly   356 STNELLDLSSLSSKPARTLLKDGKNYTIAVCAHAGAPCQENGGACYEQNSTTISLGNSNSQLRFN 420
            ||..|.||||||.:.........|.............|....|||:.|  |.||:|.::.:|.:.
Mouse  1515 STGHLFDLSSLSGRAGINASYSEKGLVFMSICEENENCGPGVGACFGQ--TRISVGKASKRLSYK 1577

  Fly   421 QTGSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSLKIIEDSNCQLLIQY 485
            .. .|.|:||:|:.|.:.:.: |:.:.|.|||...|...|       ...|..::...|.|...:
Mouse  1578 DQ-VLQLVYENGSPCPSLSDL-RYKSVISFVCRPEAGPTN-------RPMLISLDKQTCTLFFSW 1633

  Fly   486 QTPLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVELPASMEHLVPKTTKF 550
            .|||||.:...|..            .:|..:|||:|||..|..|||..|   |.:.....|..|
Mouse  1634 HTPLACEQATECTV------------RNGSSIIDLSPLIHRTGGYEAYDE---SEDDTSDTTPDF 1683

  Fly   551 FLNVCRPLVPKYQLGCAGGSAACMAKVTAAGAPEEERSMGFPLVSLTQRNRTFAELAYLKGDPCP 615
            ::|:|:||.|.:.:.|..|::.|  ||...|.|.:...:..|.:.....|..:  |.:.....|.
Mouse  1684 YINICQPLNPMHGVPCPAGASVC--KVPVDGPPIDIGRVTGPPIFNPVANEVY--LNFESSTHCL 1744

  Fly   616 TDNTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPHECTFSADTCDLVHDELGR 680
            .|.....::.|.|:|......|.|.|....||.:.|||||.:.||....|   ..|.:..::|..
Mouse  1745 ADRYMNYTSLITFHCKRGVSMGTPKLIRTNDCDFVFEWETPIVCPDEVKT---QGCAVTDEQLLY 1806

  Fly   681 RFNFKSAPFTKDGKIEIDYNATKMSVNICGAHRKAMTDYSQALVNIFFTHESPNCGREGTMNVQI 745
            .||..|.. |...|:..|  |...|:.:|.|                    :...|:||..:..:
Mouse  1807 SFNLTSLS-TSTFKVTRD--ARTYSIGVCTA--------------------AAGLGQEGCKDGGV 1848

  Fly   746 RLICSDQTESSSTISS--------DQQCNLLYVQRTP 774
            .|:..::..|...::|        |:...|.||...|
Mouse  1849 CLLSGNKGASFGRLASMQLDYRHQDEAVILSYVNGDP 1885

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LerpNP_001262996.1 CIMR <49..143 CDD:279250 24/97 (25%)
CIMR 157..298 CDD:279250 41/147 (28%)
CIMR 307..435 CDD:279250 41/132 (31%)
CIMR 445..>574 CDD:279250 37/128 (29%)
CIMR 623..>666 CDD:279250 15/42 (36%)
Igf2rNP_034645.2 CIMR 121..260 CDD:279250
ATG27 335..>467 CDD:286529
CIMR 418..567 CDD:279250
CIMR 569..709 CDD:279250
CIMR 716..868 CDD:279250
CIMR 1024..1171 CDD:279250
CIMR 1315..1455 CDD:279250 44/156 (28%)
CIMR 1459..1592 CDD:279250 41/136 (30%)
CIMR 1601..1724 CDD:279250 42/146 (29%)
CIMR 1752..1887 CDD:279250 39/160 (24%)
FN2 1890..1935 CDD:238019
CIMR 1942..2076 CDD:279250
CIMR 2234..>2273 CDD:279250
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2415..2483
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167835220
Domainoid 1 1.000 63 1.000 Domainoid score I10227
eggNOG 1 0.900 - - E1_KOG4504
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S8281
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0006150
OrthoInspector 1 1.000 - - oto93492
orthoMCL 1 0.900 - - OOG6_105199
Panther 1 1.100 - - LDO PTHR15071
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1957
SonicParanoid 1 1.000 - - X5083
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.680

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