Protein Alignment Lerp and Igf2r

DIOPT Version :10

• Sequence 1: NP_001262996.1
• Gene: Lerp / 43223
• FlyBaseID: FBgn0051072
• Length: 918
• Species: Drosophila melanogaster
• Sequence 2: NP_034645.2
• Gene: Igf2r / 16004
• MGIID: 96435
• Length: 2483
• Species: Mus musculus
• Alignment Length: 752
• Identity: 198/752 - (26%)
• Similarity: 312/752 - (41%)
• Gaps: 118/752 - (15%)

  Fly    55 CKLKEPIYGSTFDFS--GLHSDLAHVVKSMNIGGDQFEFNICGNLSR-TC---NGESNVAACLKR 113
            |::|:|.:|:.:|..  ||:..:      :::|...:...:||.||. .|   :|...|::|.::
Mouse  1220 CQVKDPRHGNLYDLKPLGLNDTI------VSVGEYTYYLRVCGKLSSDVCSAHDGSKAVSSCQEK 1278

  Fly   114 ---QGKEYILG-RQHELFYNNGNMFLKYKSGAKCDNGTADKPNYQ--LHVMFSCDYTLDAQPMHV 172
               ||.:.:.| ...:|.:.||.:.:.|..|..|..      .||  ..:.|.||.|.. :|:.:
Mouse  1279 KGPQGFQKVAGLLSQKLTFENGLLKMNYTGGDTCHK------VYQRSTTIYFYCDRTTQ-KPVFL 1336

  Fly   173 TPYANEVCSFYISYRTPLAC--LSIPEGLQSNSCRVGDTKSNGTFDLMPLS--DSNYHTSNRQGA 233
            ...::  ||:...:||..||  .::.|      |.|.|...| :.||..||  ..|:....|.||
Mouse  1337 KETSD--CSYMFEWRTQYACPPFNVTE------CSVQDAAGN-SIDLSSLSRYSDNWEAVTRTGA 1392

  Fly   234 --FFVINVCKPVL-YGENSMCPAGSSVCLFDSKATNPKERFINFGNVQTHPVVEKGQLLLRHESP 295
              .::|||||.:. :.....||..::|||.:  .:.|    :|.|.|:..|....|..:|::...
Mouse  1393 TEHYLINVCKSLSPHAGTEPCPPEAAVCLLN--GSKP----VNLGKVRDGPQWTDGVTVLQYVDG 1451

  Fly   296 TPCAKNSSANYTSVIYFSCDKFIRNAHPEFAGLGADSCTYQFNFATPLAC----NDLKPCTAFT- 355
            ..| .:.....:::|.|:|.....|:.|.|.....| |.|.|::.||.||    |....|....
Mouse  1452 DLC-PDKIRRRSTIIRFTCSDNQVNSRPLFISAVQD-CEYTFSWPTPSACPVKSNTHDDCQVTNP 1514

  Fly   356 STNELLDLSSLSSKPARTLLKDGKNYTIAVCAHAGAPCQENGGACYEQNSTTISLGNSNSQLRFN 420
            ||..|.||||||.:.........|.............|....|||:.|  |.||:|.::.:|.:.
Mouse  1515 STGHLFDLSSLSGRAGINASYSEKGLVFMSICEENENCGPGVGACFGQ--TRISVGKASKRLSYK 1577

  Fly   421 QTGSLYLLYEDGAECSTATGMRRWSTKIEFVCANNATKDNGASTAGGSDSLKIIEDSNCQLLIQY 485
            .. .|.|:||:|:.|.:.:.: |:.:.|.|||...|...|       ...|..::...|.|...:
Mouse  1578 DQ-VLQLVYENGSPCPSLSDL-RYKSVISFVCRPEAGPTN-------RPMLISLDKQTCTLFFSW 1633

  Fly   486 QTPLACREPIRCKATTYVDHTNDGLGSSGDELIDLTPLISATDNYEARVELPASMEHLVPKTTKF 550
            .|||||.:...|..            .:|..:|||:|||..|..|||..|   |.:.....|..|
Mouse  1634 HTPLACEQATECTV------------RNGSSIIDLSPLIHRTGGYEAYDE---SEDDTSDTTPDF 1683

  Fly   551 FLNVCRPLVPKYQLGCAGGSAACMAKVTAAGAPEEERSMGFPLVSLTQRNRTFAELAYLKGDPCP 615
            ::|:|:||.|.:.:.|..|::.|  ||...|.|.:...:..|.:.....|..:  |.:.....|.
Mouse  1684 YINICQPLNPMHGVPCPAGASVC--KVPVDGPPIDIGRVTGPPIFNPVANEVY--LNFESSTHCL 1744

  Fly   616 TDNTSELSTHILFNCNMRAGRGQPVLRSVEDCAYRFEWETNVFCPPHECTFSADTCDLVHDELGR 680
            .|.....::.|.|:|......|.|.|....||.:.|||||.:.||....|   ..|.:..::|..
Mouse  1745 ADRYMNYTSLITFHCKRGVSMGTPKLIRTNDCDFVFEWETPIVCPDEVKT---QGCAVTDEQLLY 1806

  Fly   681 RFNFKSAPFTKDGKIEIDYNATKMSVNICGAHRKAMTDYSQALVNIFFTHESPNCGREGTMNVQI 745
            .||..|.. |...|:..|  |...|:.:|.|                    :...|:||..:..:
Mouse  1807 SFNLTSLS-TSTFKVTRD--ARTYSIGVCTA--------------------AAGLGQEGCKDGGV 1848

  Fly   746 RLICSDQTESSSTISS--------DQQCNLLYVQRTP 774
            .|:..::..|...::|        |:...|.||...|
Mouse  1849 CLLSGNKGASFGRLASMQLDYRHQDEAVILSYVNGDP 1885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lerp	NP_001262996.1	CIMR	<49..143	CDD:425923	24/97 (25%)
		CIMR	157..298	CDD:425923	41/147 (28%)
		CIMR	307..435	CDD:425923	41/132 (31%)
		CIMR	445..>574	CDD:425923	37/128 (29%)
		CIMR	623..>666	CDD:425923	15/42 (36%)
Igf2r	NP_034645.2	CIMR	121..260	CDD:425923
		ATG27	323..>467	CDD:476860
		CIMR	418..567	CDD:425923
		CIMR	569..709	CDD:425923
		CIMR	716..868	CDD:425923
		CIMR	1024..1171	CDD:425923
		ATG27	1219..>1355	CDD:476860	37/149 (25%)
		CIMR	1315..1455	CDD:425923	44/156 (28%)
		CIMR	1459..1592	CDD:425923	41/136 (30%)
		CIMR	1601..1724	CDD:425923	42/146 (29%)
		CIMR	1752..1887	CDD:425923	39/160 (24%)
		FN2	1890..1935	CDD:238019
		CIMR	1942..2076	CDD:425923
		CIMR	2234..>2273	CDD:425923
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2415..2483