DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tl and RLP15

DIOPT Version :9

Sequence 1:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_177559.1	Gene:	RLP15 / 843759	AraportID:	AT1G74190	Length:	965	Species:	Arabidopsis thaliana

Alignment Length:	968	Identity:	219/968 - (22%)
Similarity:	348/968 - (35%)	Gaps:	325/968 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 DMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWSNQLHNL 236
            |:|:|:....|.      |.||||:|..:|:.               |:.||:.|:|.||:.:|.
plant   104 DVRSLNLSSSRC------SGLFDDVEGYKSLR---------------KLRKLEILDLASNKFNNS 147

  Fly   237 TKHDFEGATSVLGIDIHDNGIE-QLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHLNEVRL 300
            ..|....|||:..:.:..|.:: ..|......|||:..::||.|.|
plant   148 IFHFLSAATSLTTLFLRSNNMDGSFPAKELRDLTNLELLDLSRNRF------------------- 193

  Fly   301 MNNRVPLATLPSRLFANQPELQILRLRAELQSLPGDLFEHSTQITNISLGDNLLKTLPATLLEHQ 365
             |..:|:..|.|          :.:|:|  ..|.|:.|..|.::......| ||.::.:.:.|..
plant   194 -NGSIPIQELSS----------LRKLKA--LDLSGNEFSGSMELQGKFCTD-LLFSIQSGICELN 244

  Fly   366 VNLLSLDLSNNRLT-HLPDSLFAHTTNLTDLR---LEDNLLTG---------------------- 404
             |:..||||.|:|. |||..|    |:||.||   |..|.|||
plant   245 -NMQELDLSQNKLVGHLPSCL----TSLTGLRVLDLSSNKLTGTVPSSLGSLQSLEYLSLFDNDF 304

  Fly   405 ---ISGDIFSNLGNLVTL----------VMSRN------RLRTIDSRA---------FVSTNGLR 441
               .|....:||.||:.|          |:|.:      :|..|..|:         .:....||
plant   305 EGSFSFGSLANLSNLMVLKLCSKSSSLQVLSESSWKPKFQLSVIALRSCNMEKVPHFLLHQKDLR 369

  Fly   442 HLHLDHNDIDLQQP---------LLDIMLQTQINSPFGY---MHGLLTLNLRNNSIIFVYND--- 491
            |:.|..|:|..:.|         |..::||..:.:.|..   .|.||.|::..|....::.:
plant   370 HVDLSDNNISGKLPSWLLANNTKLKVLLLQNNLFTSFQIPKSAHNLLFLDVSANDFNHLFPENIG 434

  Fly   492 WKNTMLQLRELDLSYNNI-----SSLG------YEDLAFLSQNRLHVN----------------M 529
            |  ....||.|:.|.||.     ||||      |.|   ||:|..|.|                :
plant   435 W--IFPHLRYLNTSKNNFQENLPSSLGNMNGIQYMD---LSRNSFHGNLPRSFVNGCYSMAILKL 494

  Fly   530 THNKIRRIALPEDVH-----------------LGEGY------------NNNLVHVD-------- 557
            :|||:.....||..:                 :|:|.            ||||..|.
plant   495 SHNKLSGEIFPESTNFTNILGLFMDNNLFTGKIGQGLRSLINLELLDMSNNNLTGVIPSWIGELP 559

  Fly   558 ------LNDNPLVCDCTILWF----IQL-------VRGVHKPQYSRQFKLRTDRLVCSQPNVLEG 605
                  ::||.|..|..:..|    :||       :.||..||:..    |...::..|.|.|.|
plant   560 SLTALLISDNFLKGDIPMSLFNKSSLQLLDLSANSLSGVIPPQHDS----RNGVVLLLQDNKLSG 620

  Fly   606 TPVRQIEPQTLICPLDFSDDPRER---KCPRGCNCHVRTYDKALVI-NCHSGNLTHVPRLPNLHK 666
            |     .|.||:..::..|....|   |.|...|  ::.....|:. |..:|.:.|  :|..| .
plant   621 T-----IPDTLLANVEILDLRNNRFSGKIPEFIN--IQNISILLLRGNNFTGQIPH--QLCGL-S 675

  Fly   667 NMQLMELHLENNTLLRLPSANTPGYESVTSLHLAGNNLTSIDVD---QLPTNL-----THLDISW 723
            |:||::  |.||.|    :...|...|.||... |...||.|.|   ..|:::     .|.|.|.
plant   676 NIQLLD--LSNNRL----NGTIPSCLSNTSFGF-GKECTSYDYDFGISFPSDVFNGFSLHQDFSS 733

  Fly   724 NHLQMLNATVLGFLNRTMKWRSVKLSGNPWMCD---CTAKPLLLFTQDNFERIGDRNEMMCVNAE 785
            |.            |..:.::|: |:.:|...|   .|...:...|:..::.....|..:...
plant   734 NK------------NGGIYFKSL-LTLDPLSMDYKAATQTKIEFATKHRYDAYMGGNLKLLFG-- 783

  Fly   786 MPTRMVELSTNDI---CPAEKGVFIALAVVIA----LTGLLAGFTAAL---------YYKFQ--- 831
                 ::||.|::   .|.|.|..:.|..:..    |:|::....:::         :.:.|
plant   784 -----MDLSENELSGEIPVEFGGLLELRALNLSHNNLSGVIPKSISSMEKMESFDLSFNRLQGRI 843

  Fly   832 -------TEIKIWLYAHNLLLWFVTEEDLDKDKKFDAFISYSHKDQSFIEDYLVPQLEHGPQKFQ 889
                   |.:.::..:||.|...:.:     .::|:.|.:         |.|...:|..|....:
plant   844 PSQLTELTSLSVFKVSHNNLSGVIPQ-----GRQFNTFDA---------ESYFGNRLLCGQPTNR 894

  Fly   890 LC----VHERDWLVGGHIPENIM------RSVADSRRTII--VLSQNFIKSEWARLEF 935
            .|    ..|.|  .|....|:|:      .|.|.:..||:  :|:.....|.|:|..|
plant   895 SCNNNSYEEAD--NGVEADESIIDMVSFYLSFAAAYVTILIGILASLSFDSPWSRFWF 950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	17/58 (29%)
		leucine-rich repeat	176..198	CDD:275380	7/21 (33%)
		leucine-rich repeat	199..222	CDD:275380	2/22 (9%)
		LRR_RI	216..542	CDD:238064	105/422 (25%)
		LRR_8	221..281	CDD:290566	19/60 (32%)
		leucine-rich repeat	223..270	CDD:275380	13/47 (28%)
		leucine-rich repeat	271..294	CDD:275380	4/22 (18%)
		leucine-rich repeat	295..320	CDD:275380	4/24 (17%)
		leucine-rich repeat	321..343	CDD:275380	6/21 (29%)
		LRR_8	342..402	CDD:290566	22/63 (35%)
		leucine-rich repeat	344..367	CDD:275380	4/22 (18%)
		leucine-rich repeat	368..391	CDD:275380	10/23 (43%)
		LRR_8	390..450	CDD:290566	26/112 (23%)
		leucine-rich repeat	392..415	CDD:275380	12/50 (24%)
		leucine-rich repeat	416..439	CDD:275380	7/47 (15%)
		leucine-rich repeat	440..474	CDD:275380	11/45 (24%)
		leucine-rich repeat	475..498	CDD:275380	5/25 (20%)
		LRR_8	477..534	CDD:290566	22/86 (26%)
		leucine-rich repeat	499..520	CDD:275380	12/31 (39%)
		leucine-rich repeat	523..552	CDD:275380	11/73 (15%)
		LRRCT	561..619	CDD:214507	19/68 (28%)
		LRRNT	631..667	CDD:214470	8/36 (22%)
		leucine-rich repeat	664..693	CDD:275380	9/28 (32%)
		LRR_8	669..726	CDD:290566	20/64 (31%)
		leucine-rich repeat	694..715	CDD:275380	8/23 (35%)
		leucine-rich repeat	716..737	CDD:275380	4/25 (16%)
		LRRCT	751..800	CDD:214507	8/54 (15%)
		TIR	858..996	CDD:214587	21/90 (23%)
RLP15	NP_177559.1	LRRNT_2	28..72	CDD:369783
		PLN00113	<105..>287	CDD:215061	66/240 (28%)
		leucine-rich repeat	106..133	CDD:275380	11/47 (23%)
		leucine-rich repeat	134..157	CDD:275380	8/22 (36%)
		leucine-rich repeat	158..182	CDD:275380	3/23 (13%)
		leucine-rich repeat	183..207	CDD:275380	8/53 (15%)
		leucine-rich repeat	208..245	CDD:275380	10/40 (25%)
		leucine-rich repeat	246..269	CDD:275380	12/26 (46%)
		PLN00113	249..>892	CDD:215061	157/706 (22%)
		leucine-rich repeat	270..293	CDD:275380	7/22 (32%)
		leucine-rich repeat	294..318	CDD:275380	3/23 (13%)
		leucine-rich repeat	319..357	CDD:275380	7/37 (19%)
		leucine-rich repeat	368..392	CDD:275380	7/23 (30%)
		leucine-rich repeat	440..463	CDD:275380	10/22 (45%)
		leucine-rich repeat	465..488	CDD:275380	7/25 (28%)
		leucine-rich repeat	489..512	CDD:275380	5/22 (23%)
		leucine-rich repeat	513..536	CDD:275380	2/22 (9%)
		leucine-rich repeat	537..560	CDD:275380	5/22 (23%)
		leucine-rich repeat	561..584	CDD:275380	5/22 (23%)
		leucine-rich repeat	585..607	CDD:275380	6/25 (24%)
		leucine-rich repeat	608..629	CDD:275380	8/25 (32%)
		leucine-rich repeat	630..652	CDD:275380	5/23 (22%)
		leucine-rich repeat	653..676	CDD:275380	6/25 (24%)
		leucine-rich repeat	677..697	CDD:275380	7/25 (28%)
		leucine-rich repeat	744..804	CDD:275380	12/67 (18%)
		leucine-rich repeat	749..780	CDD:275380	5/30 (17%)
		leucine-rich repeat	805..828	CDD:275380	3/22 (14%)
		leucine-rich repeat	829..850	CDD:275380	1/20 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	125	1.000	Inparanoid score	I1937
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.050